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[健康技术员学生中的麻疹、风疹、腮腺炎和水痘血清阳性率:一项血清流行率研究]

[Measles, Rubella, Mumps and Varicella Seropositivity in Health Technician Students: A Seroprevalence Study].

作者信息

Açikgöz Ayla, Kizildağ Servet, Appak Özgür, Çimrin Dilek, Esen Nuran, Sayiner Ayça Arzu

机构信息

Dokuz Eylül University Vocational School of Health Services, Department of Medical Services and Techniques, İzmir, Türkiye.

Dokuz Eylül University Faculty of Medicine, Department of Medical Microbiology, İzmir, Türkiye.

出版信息

Mikrobiyol Bul. 2024 Oct;58(4):471-479. doi: 10.5578/mb.20249653.

DOI:10.5578/mb.20249653
PMID:39745218
Abstract

Measles, rubella, mumps and chickenpox infections are among the childhood diseases that can be prevented by vaccination. Healthcare workers are at greater risk of diseases transmitted through contact with patients' respiratory secretions, infected blood and body fluids. Students studying in the field of health are at the risk of encountering infectious diseases as much as healthcare personnel during their internship and practice experience in healthcare institutions during their education. In addition, due to the risk of these students becoming a source of contamination to the patients they encounter, it is important to know their immunity against infectious diseases, to take protective measures before encountering patients and to implement the necessary vaccination programs. The aim of this study was to determine the seroprevalence of vaccine-preventable diseases such as measles, rubella, mumps and chickenpox among health technician students studying at Dokuz Eylül University Vocational School of Health Services. The population of this cross-sectional study consisted of second-year students at Dokuz Eylül University Vocational School of Health Services. Five hundred fifty health technician students participated in the research. The data of the study was obtained by survey and serology results. The survey included questions regarding the students' sociodemographic characteristics (age, gender, place of residence during childhood); information about their families (education level of mother and father, economic status of the family); presence of a history of measles, rubella, mumps and chickenpox; and history of vaccination against measles, rubella, mumps and chickenpox. Specific IgG type antibodies to measles, rubella, mumps and varicella viruses were determined using ELISA kits. IgG test results of these diseases were classified as qualitative (positive or negative). In this study, measles, rubella, mumps and chickenpox seropositivity in students was found to be 21.8%, 89.3%, 64.7%, 92.9%, respectively. Measles seropositivity was higher in students aged ≥21 years and with low income levels. Rubella seropositivity was higher in students who lived in rural areas and had low income during their childhood. Mumps and chickenpox seropositivity was higher in students who reported having mumps and chickenpox. Chickenpox seropositivity was higher in students who lived in rural areas during their childhood. In conclusion, in this study, we found that there was a significant proportion of health students who did not have protective levels of measles and mumps antibodies. This was much more evident for measles. Considering the higher risk of infection in health technician students, these vulnerable students may be recommended to receive the third dose of measles-mumps-rubella vaccine, regardless of their vaccination history. Additionally, conducting larger-scale studies on students with definitive vaccination records may allow obtaining more detailed information about the status of protection against these diseases.

摘要

麻疹、风疹、腮腺炎和水痘感染是可通过接种疫苗预防的儿童疾病。医护人员因接触患者的呼吸道分泌物、感染的血液和体液而面临更高的疾病传播风险。在卫生领域学习的学生在其教育期间于医疗机构实习和实践时,与医护人员一样有接触传染病的风险。此外,由于这些学生有可能成为他们接触的患者的污染源,了解他们对传染病的免疫力、在接触患者前采取保护措施并实施必要的疫苗接种计划非常重要。本研究的目的是确定在多库兹艾于勒大学卫生服务职业学校学习的卫生技术专业学生中麻疹、风疹、腮腺炎和水痘等疫苗可预防疾病的血清阳性率。这项横断面研究的人群包括多库兹艾于勒大学卫生服务职业学校的二年级学生。550名卫生技术专业学生参与了该研究。研究数据通过调查和血清学结果获得。调查包括有关学生社会人口学特征(年龄、性别、童年居住地点)的问题;关于他们家庭的信息(父母的教育水平、家庭经济状况);麻疹、风疹、腮腺炎和水痘病史;以及麻疹、风疹、腮腺炎和水痘疫苗接种史。使用酶联免疫吸附测定试剂盒测定针对麻疹、风疹、腮腺炎和水痘病毒的特异性IgG型抗体。这些疾病的IgG检测结果分为定性(阳性或阴性)。在本研究中,学生中麻疹、风疹、腮腺炎和水痘的血清阳性率分别为21.8%、89.3%、64.7%、92.9%。≥21岁且收入水平低的学生麻疹血清阳性率较高。童年生活在农村地区且收入低的学生风疹血清阳性率较高。报告有腮腺炎和水痘病史的学生腮腺炎和水痘血清阳性率较高。童年生活在农村地区的学生水痘血清阳性率较高。总之,在本研究中,我们发现有相当比例的卫生专业学生没有达到具有保护作用水平的麻疹和腮腺炎抗体。麻疹方面更为明显。考虑到卫生技术专业学生感染风险较高,无论其疫苗接种史如何,可能建议这些易感染学生接种第三剂麻疹 - 腮腺炎 - 风疹疫苗。此外,对有明确疫苗接种记录的学生进行更大规模的研究可能会获得有关这些疾病防护状况的更详细信息。

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