Christensen Lanette M, Levine Matthew H
Department of Surgery, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Department of Surgery, University of Pennsylvania, Philadelphia, Pennsylvania, USA; Department of Surgery, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
Kidney Int. 2025 Jan;107(1):10-12. doi: 10.1016/j.kint.2024.10.017.
A current study by Kitai et al. found that ovariectomy before estrogen/female sex hormone sensitization at puberty provided protection against kidney ischemia reperfusion injury, challenging the general consensus within the field that estrogen provides renoprotective function. These results are intriguing and could have important clinical implications, while requiring some clarification and substantiation of the conclusions reported.
北井等人目前的一项研究发现，在青春期雌激素/雌性激素致敏之前进行卵巢切除术可预防肾脏缺血再灌注损伤，这对该领域内认为雌激素具有肾脏保护功能的普遍共识提出了挑战。这些结果很有趣，可能具有重要的临床意义，同时需要对所报道的结论进行一些澄清和证实。
