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Chronic stress induces senescence build-up early in life.

作者信息

Lau Victor, Awogbindin Ifeoluwa, Tremblay Marie-Ève

机构信息

University of Victoria, Victoria, British Columbia, Canada.

出版信息

Nat Aging. 2025 Jan;5(1):12-14. doi: 10.1038/s43587-024-00774-1.

DOI:10.1038/s43587-024-00774-1
PMID:39747653
Abstract
摘要

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Glyoxal Induces Senescence in Human Keratinocytes through Oxidative Stress and Activation of the Protein Kinase B/FOXO3a/p27 Pathway.乙二醛通过氧化应激和激活蛋白激酶 B/FOXO3a/p27 通路诱导人角质形成细胞衰老。
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本文引用的文献

1
Chronic social stress induces p16-mediated senescent cell accumulation in mice.慢性社会应激诱导小鼠体内p16介导的衰老细胞积累。
Nat Aging. 2025 Jan;5(1):48-64. doi: 10.1038/s43587-024-00743-8. Epub 2024 Nov 11.
2
Defining and characterizing neuronal senescence, 'neurescence', as G arrested cells.将神经元衰老(“神经衰老”)定义并表征为处于G期停滞的细胞。
Trends Neurosci. 2024 Dec;47(12):971-984. doi: 10.1016/j.tins.2024.09.006. Epub 2024 Oct 9.
3
Guidelines for minimal information on cellular senescence experimentation in vivo.
体内细胞衰老实验的最低信息指南。
Cell. 2024 Aug 8;187(16):4150-4175. doi: 10.1016/j.cell.2024.05.059.
4
Sexual dimorphic metabolic and cognitive responses of C57BL/6 mice to Fisetin or Dasatinib and quercetin cocktail oral treatment.黄酮或达沙替尼和槲皮素鸡尾酒口服治疗对 C57BL/6 小鼠代谢和认知功能的性别二态性影响。
Geroscience. 2023 Oct;45(5):2835-2850. doi: 10.1007/s11357-023-00843-0. Epub 2023 Jun 9.
5
An aging, pathology burden, and glial senescence build-up hypothesis for late onset Alzheimer's disease.衰老、病理学负担和神经胶质衰老积累假说解释迟发性阿尔茨海默病。
Nat Commun. 2023 Mar 25;14(1):1670. doi: 10.1038/s41467-023-37304-3.
6
Hallmarks of aging: An expanding universe.衰老的特征:一个不断扩大的领域。
Cell. 2023 Jan 19;186(2):243-278. doi: 10.1016/j.cell.2022.11.001. Epub 2023 Jan 3.
7
Stress-induced biological aging: A review and guide for research priorities.应激相关的生物老化:综述与研究重点指导。
Brain Behav Immun. 2022 Aug;104:97-109. doi: 10.1016/j.bbi.2022.05.016. Epub 2022 May 31.
8
Mechanisms and therapeutic implications of cellular senescence in osteoarthritis.细胞衰老在骨关节炎中的机制和治疗意义。
Nat Rev Rheumatol. 2021 Jan;17(1):47-57. doi: 10.1038/s41584-020-00533-7. Epub 2020 Nov 18.
9
Cellular Senescence: Defining a Path Forward.细胞衰老:定义前进的道路。
Cell. 2019 Oct 31;179(4):813-827. doi: 10.1016/j.cell.2019.10.005.
10
Clearance of senescent glial cells prevents tau-dependent pathology and cognitive decline.清除衰老的神经胶质细胞可预防tau 依赖性病变和认知能力下降。
Nature. 2018 Oct;562(7728):578-582. doi: 10.1038/s41586-018-0543-y. Epub 2018 Sep 19.