O'Neill P, Bell B A, Miller J D, Jacobson I, Guthrie W
Neurosurgery. 1985 Feb;16(2):166-70. doi: 10.1227/00006123-198502000-00007.
We report the clinical presentation and management of 34 patients with a histologically proven chordoma, treated in the neurosurgical departments in Edinburgh and Dundee, over the past 50 years. Although these tumors are commonly regarded as being locally invasive with a variable, but generally slow growth rate, they can metastasize, and this may precede surgical intervention, as in one of our patients. Our cases are compared to those in previously published series, and a comprehensive review of the treatment modalities for tumors at various sites is presented. The optimal treatment to be recommended from our own experience, and that of others, is aggressive operation and radiotherapy. A combination of hyperthermia and chemotherapy has shown some promise, but remains untested, and highlights the need for a multicenter trial with long follow-up to allow the evaluation of new therapeutic approaches.
我们报告了过去50年里在爱丁堡和邓迪的神经外科接受治疗的34例经组织学证实的脊索瘤患者的临床表现及治疗情况。尽管这些肿瘤通常被认为具有局部侵袭性，生长速度不一但总体缓慢，不过它们可能会发生转移，正如我们其中一位患者那样，转移可能在手术干预之前就已出现。我们将这些病例与先前发表系列研究中的病例进行了比较，并对不同部位肿瘤的治疗方式进行了全面综述。根据我们自己以及他人的经验，推荐的最佳治疗方法是积极手术和放疗。热疗与化疗相结合已显示出一定前景，但仍未经过检验，这凸显了开展一项长期随访的多中心试验以评估新治疗方法的必要性。
