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从慢性伤口或血流感染中分离出的菌株所产生的毒力因子的比较分析。

Comparative analysis of virulence factors produced by strains isolated from chronic wounds or bloodstream infections.

作者信息

Teixeira Felipe L, Pauer Heidi, Valente Gabriel Luis C, de Paula Geraldo Renato

机构信息

Department of Molecular Biosciences, University of Kansas, Lawrence, Kansas, United States.

Departamento de Tecnologia Farmacêutica, Universidade Federal Fluminense, Niterói, Rio de Janeiro, Brazil.

出版信息

MicroPubl Biol. 2024 Dec 18;2024. doi: 10.17912/micropub.biology.001413. eCollection 2024.

DOI:10.17912/micropub.biology.001413
PMID:39748833
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11688615/
Abstract

is an important pathogen associated with both chronic wounds and bloodstream infections. Virulence factors required for the establishment of acute and chronic infections differ substantially. Since bacteremia can be a severe outcome of wound colonization, we performed a comparative analysis of virulence between strains isolated from the bloodstream and chronic wounds. Our results show that, in general, strains isolated from bloodstream infections are more virulent than strains that colonize chronic wounds.

摘要

是一种与慢性伤口和血流感染相关的重要病原体。建立急性和慢性感染所需的毒力因子有很大差异。由于菌血症可能是伤口定植的严重后果，我们对从血流和慢性伤口分离出的菌株之间的毒力进行了比较分析。我们的结果表明，一般来说，从血流感染中分离出的菌株比定植于慢性伤口的菌株毒力更强。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/35e9/11688615/5e63c3159b3b/25789430-2024-micropub.biology.001413.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/35e9/11688615/5e63c3159b3b/25789430-2024-micropub.biology.001413.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/35e9/11688615/5e63c3159b3b/25789430-2024-micropub.biology.001413.jpg

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本文引用的文献

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Pseudomonas aeruginosa: pathogenesis, virulence factors, antibiotic resistance, interaction with host, technology advances and emerging therapeutics.
铜绿假单胞菌：发病机制、毒力因子、抗生素耐药性、与宿主的相互作用、技术进展和新兴治疗方法。
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Molecular Analysis of the Contribution of Alkaline Protease A and Elastase B to the Virulence of Bloodstream Infections.碱性蛋白酶 A 和弹性蛋白酶 B 对血流感染毒力的分子分析。
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