Fang Yanke, Chen Xin, Chu Chun Hung, Yu Ollie Yiru, He Jinzhi, Li Mingyun
State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China School of Stomatology, Sichuan University, Chengdu, China.
Faculty of Dentistry, The University of Hong Kong, Hong Kong, Hong Kong SAR, China.
Front Microbiol. 2024 Dec 19;15:1503657. doi: 10.3389/fmicb.2024.1503657. eCollection 2024.
() is the main pathogenic bacterium causing dental caries, and the modes in which its traits, such as acid production, acid tolerance, and adhesion that contribute to the dental caries process, has been clarified. However, a growing number of animal experiments and clinical revelations signify that these traits of are not restricted to the detriment of dental tissues. These traits can assist in evading the immune system within body fluids; they empower to adhere not merely to the surface of teeth but also to other tissues such as vascular endothelium; they can additionally trigger inflammatory reactions and inflict damage on various organs, thereby leading to the occurrence of systemic diseases. These traits mostly originate from some correlative findings, lacking a comprehensive evaluation of the impact of on systemic diseases. Therefore, this review mainly centers on the dissemination route of : "Entering the blood circulation - Occurrence of tissue adhesion - Extensive possible proinflammatory mechanisms - Concentration in individual organs" and analyses the specific effects and possible mechanisms of in systemic diseases such as cerebral hemorrhage, inflammatory bowel disease, tumors, and infective endocarditis that have been identified hitherto.
（）是导致龋齿的主要病原菌，其产酸、耐酸和黏附等有助于龋齿形成过程的特性的作用方式已得到阐明。然而，越来越多的动物实验和临床发现表明，（）的这些特性并不局限于对牙齿组织的损害。这些特性可帮助（）在体液中逃避免疫系统；使（）不仅能黏附于牙齿表面，还能黏附于其他组织，如血管内皮；它们还可引发炎症反应并对各种器官造成损害，从而导致全身性疾病的发生。这些特性大多源于一些相关发现，缺乏对（）对全身性疾病影响的全面评估。因此，本综述主要围绕（）的传播途径：“进入血液循环 - 发生组织黏附 - 广泛可能的促炎机制 - 在各个器官中的聚集”，并分析了（）在迄今已确定的全身性疾病，如脑出血、炎症性肠病、肿瘤和感染性心内膜炎中的具体作用及可能机制。
