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J Am Chem Soc. 2024 Aug 28;146(34):23674-23679. doi: 10.1021/jacs.4c07690. Epub 2024 Aug 19.
2
Rapid and scalable photocatalytic C(sp)-C(sp) Suzuki-Miyaura cross-coupling of aryl bromides with alkyl boranes.芳基溴化物与烷基硼烷的快速且可扩展的光催化C(sp)-C(sp)铃木-宫浦交叉偶联反应。
Nat Commun. 2024 May 13;15(1):4028. doi: 10.1038/s41467-024-48212-5.
3
Rhodium-Catalyzed Asymmetric Synthesis of 1,2-Disubstituted Allylic Fluorides.铑催化的1,2-二取代烯丙基氟化物的不对称合成
Angew Chem Int Ed Engl. 2023 Nov 27;62(48):e202314843. doi: 10.1002/anie.202314843. Epub 2023 Oct 27.
4
Scope and Mechanistic Probe into Asymmetric Synthesis of α-Trisubstituted-α-Tertiary Amines by Rhodium Catalysis.铑催化α-三取代-α-叔胺不对称合成的范围及机理探究
J Am Chem Soc. 2023 Sep 13;145(36):19642-19654. doi: 10.1021/jacs.3c04211. Epub 2023 Aug 31.
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Chiral Diene Ligands in Asymmetric Catalysis.手性二烯配体在不对称催化中的应用。
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Advances and applications of chiral resolution in pharmaceutical field.手性拆分在制药领域的进展与应用
Chirality. 2022 Aug;34(8):1094-1119. doi: 10.1002/chir.23453. Epub 2022 Jun 8.
7
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Enantioconvergent Amination of Racemic Tertiary C-H Bonds.对映选择性胺化外消旋三级 C-H 键。
J Am Chem Soc. 2020 Dec 9;142(49):20902-20911. doi: 10.1021/jacs.0c11103. Epub 2020 Nov 29.
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Stereodivergent Pd/Cu Catalysis for the Dynamic Kinetic Asymmetric Transformation of Racemic Unsymmetrical 1,3-Disubstituted Allyl Acetates.立体发散性 Pd/Cu 催化对映体非对称 1,3-二取代烯丙基乙酸酯的动态动力学不对称转化。
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铑催化的烯丙基胺化反应用于对映选择性合成叔β-氟代胺

Rhodium-Catalyzed Allylic Amination for the Enantioselective Synthesis of Tertiary β-Fluoroamines.

作者信息

Chukwu Felix O, Arachchi Madhawee K, Nguyen Hien M

机构信息

Department of Chemistry, Wayne State University, Detroit, Michigan 48202, United States.

出版信息

Org Lett. 2025 Jan 17;27(2):594-599. doi: 10.1021/acs.orglett.4c04289. Epub 2025 Jan 3.

DOI:10.1021/acs.orglett.4c04289
PMID:39749994
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11804973/
Abstract

The utilization of β-fluoroamines as pharmaceutical components for drug development has attracted a considerable amount of interest. However, direct access to tertiary β-fluoroamines is challenging. We herein report the rhodium-catalyzed asymmetric amination of tertiary allylic trichloroacetimidates with anilines and cyclic aliphatic amines to access tertiary β-fluoroamines, where the α-carbon atom is bonded to four different substituents, in good yield with high levels of enantioselectivity.

摘要

将β-氟胺用作药物开发的药物成分已引起了相当大的关注。然而，直接获得叔β-氟胺具有挑战性。我们在此报告了铑催化叔烯丙基三氯乙酰亚胺与苯胺和环状脂肪胺的不对称胺化反应，以获得α-碳原子与四个不同取代基相连的叔β-氟胺，产率良好且对映选择性高。