Lee Yun-Gyoo, Seo Dayeon, Gil Hyun-Il, Koo Dong-Hoe, Oh Suk Joong
Division of Hematology & Medical Oncology, Department of Internal Medicine, Samsung Kangbuk Hospital, Sungkyunkwan University School of Medicine, 29 Saemunan-ro, Jongno-gu, Seoul, 03181, Republic of Korea.
Sungkyunkwan University School of Medicine, Suwon, Republic of Korea.
Ann Hematol. 2025 Jan;104(1):401-406. doi: 10.1007/s00277-024-06159-z. Epub 2025 Jan 3.
Tuberculosis (TB) is associated with chronic inflammation, which has been implicated in the pathogenesis of various malignancies, including lung cancer. However, the relationship between TB and hematological malignancies like lymphoma remains less understood. This study aimed to investigate risks of incident malignant lymphoma according to previous TB infection in a large prospective cohort of 347,204 individuals. Multiple logistic regression analyses were conducted to predict the probability of malignant lymphoma. Propensity score matching was employed to compare the incidence of lymphoma in individuals with and without previous TB infection. Among the overall population, 3.7% (12,694) reported previous history of TB. There was a significantly increased risk of lymphoma in individuals with a TB history, with an odds ratio of 2.14 (95% confidence interval (CI): 1.35-3.39, p = 0.001) and a hazard ratio of 2.13 (95% CI, 1.13-4.00; p = 0.019) in propensity-matched analyses. These findings underscore TB infection as a potential precursor to lymphoma, probably due to prolonged inflammatory and immune dysregulation. The study highlights the importance of considering a TB history in the risk assessment for lymphoma, emphasizing the need for vigilant clinical monitoring in population with high TB burden.
结核病（TB）与慢性炎症相关，慢性炎症与包括肺癌在内的各种恶性肿瘤的发病机制有关。然而，结核病与淋巴瘤等血液系统恶性肿瘤之间的关系仍不太清楚。本研究旨在调查在一个347,204人的大型前瞻性队列中，既往结核感染与新发恶性淋巴瘤风险之间的关系。进行了多项逻辑回归分析以预测恶性淋巴瘤的发生概率。采用倾向评分匹配法比较既往有和无结核感染个体的淋巴瘤发病率。在总体人群中，3.7%（12,694人）报告有结核病史。有结核病史的个体患淋巴瘤的风险显著增加，倾向评分匹配分析中的优势比为2.14（95%置信区间（CI）：1.35 - 3.39，p = 0.001）以及风险比为2.13（95% CI，1.13 - 4.00；p =0.019）。这些发现强调结核感染可能是淋巴瘤的潜在先兆，可能是由于长期的炎症和免疫失调。该研究强调在淋巴瘤风险评估中考虑结核病史的重要性，强调对结核负担高的人群进行 vigilant 临床监测的必要性。
原文中“vigilant”未翻译完整，可能是输入有误，如果是“vigilant”完整的话，可译为“警惕的；警觉的” ，整句意思为强调对结核负担高的人群进行警惕性临床监测的必要性 。你可根据实际情况进行调整 。
