Tanwar Ankur Kumar, Chatterjee Debanjan, Jain Neha, Sharma Shivam, Tikoo Kulbhushan, Singh Inder Pal
J Nat Prod. 2025 Jan 24;88(1):15-23. doi: 10.1021/acs.jnatprod.3c00975. Epub 2025 Jan 3.
Certain medicinal plants utilized in the traditional ayurvedic system are poisonous when used raw, but are used following a detoxification process. The Ayurvedic Formulary of India (AFI) provides details about these detoxification (known as "sodhana") processes as per traditional procedures. This research endeavor aimed to uncover the fundamental principles underlying the detoxification approach applied to , commonly referred to as "swet chitrak", in which plumbagin is the primary toxic constituent. Both unprocessed and processed (detoxified) extracts as well as the detoxification media were subjected to analysis for secondary metabolites using different analytical techniques. This investigation revealed a reduction in plumbagin content, its conversion to epoxyplumbagin and zeylanone and a noteworthy decrease in - and -isoshinanolone during detoxification. Furthermore, it was confirmed that pure plumbagin when subjected to the same detoxification conditions, is partially converted into epoxyplumbagin, and that and -isoshinanolone showed interconversion. The current work establishes the chemical basis of the age-old traditional ayurvedic process of detoxification of .
在传统阿育吠陀体系中使用的某些药用植物，未经加工时有毒，但经过解毒过程后使用。《印度阿育吠陀配方》（AFI）按照传统程序提供了这些解毒（称为“sodhana”）过程的详细信息。本研究旨在揭示应用于通常称为“swet chitrak”（其主要有毒成分是白花丹醌）的解毒方法的基本原理。使用不同的分析技术对未加工和加工（解毒）提取物以及解毒介质进行次生代谢物分析。该研究表明，解毒过程中白花丹醌含量降低，其转化为环氧白花丹醌和泽兰酮，并且α-和β-异辛南酮显著减少。此外，已证实纯白花丹醌在相同解毒条件下会部分转化为环氧白花丹醌，并且α-和β-异辛南酮会相互转化。目前的工作确立了古老的传统阿育吠陀对swet chitrak解毒过程的化学基础。
