Yang Nan, Yang Yunchuan, Zhang Wanqi, Li Xinying, Jiang Hao, Kou Huiling, Zhang Junbo, Wang Yuanyuan, Tan Liuchang, Lu Yuangang
Department of Plastic & Cosmetic Surgery, Daping Hospital, Army Medical University, Chongqing 400042, China.
Department of Plastic & Cosmetic Surgery, Daping Hospital, Army Medical University, Chongqing 400042, China.
Photodiagnosis Photodyn Ther. 2025 Feb;51:104469. doi: 10.1016/j.pdpdt.2024.104469. Epub 2025 Jan 1.
Cutaneous squamous cell carcinoma (cSCC) is an aggressive tumor with unclear margins. Photodynamic diagnosis (PDD) enables the differentiation of tumor tissue from normal tissue via visible fluorescence. Photodynamic therapy (PDT) is widely used in the treatment of non-melanoma skin tumors. This study aims to illustrate the efficacy and safety of PDD-guided tumor excision combined with ALA-PDT in patients with cSCC.
This study involved 23 cSCC patients, randomly assigned to the PDD group (n = 11) and the non-PDD group (n = 12). Patients in the PDD group underwent tumor excision guided by PDD, while those in the non-PDD group received wide local excision (WLE). Both groups were subjected to frozen section analysis, and PDT was applied during and post-surgery.
The negative margin rate in the PDD group was 98.6 %, significantly higher than the 69.2 % observed in the non-PDD group. The PDD group required fewer frozen section analyses and experienced reduced surgical duration.
PDD effectively delineates tumor margins in cSCC, guiding the scope of surgical excision. The integration of PDD-guided resection with PDT offers a highly safe and effective therapeutic strategy for cSCC.
皮肤鳞状细胞癌（cSCC）是一种边界不清晰的侵袭性肿瘤。光动力诊断（PDD）可通过可见荧光区分肿瘤组织与正常组织。光动力疗法（PDT）广泛应用于非黑素瘤皮肤肿瘤的治疗。本研究旨在阐明PDD引导下肿瘤切除联合ALA-PDT治疗cSCC患者的疗效和安全性。
本研究纳入23例cSCC患者，随机分为PDD组（n = 11）和非PDD组（n = 12）。PDD组患者在PDD引导下进行肿瘤切除，而非PDD组患者接受广泛局部切除（WLE）。两组均进行冰冻切片分析，并在手术期间及术后应用PDT。
PDD组的切缘阴性率为98.6%，显著高于非PDD组的69.2%。PDD组所需的冰冻切片分析次数更少，手术时间也更短。
PDD能有效勾勒cSCC的肿瘤边界，指导手术切除范围。PDD引导下的切除与PDT相结合为cSCC提供了一种高度安全有效的治疗策略。
