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基于风险的方法可以指导安全的细胞系开发和细胞库建设，以实现规模化的养殖肉类生产。

A risk-based approach can guide safe cell line development and cell banking for scaled-up cultivated meat production.

作者信息

Bennie Rachel Zoe, Ogilvie Olivia Janice, Loo Larry Sai Weng, Zhou Hanzhang, Ng Say Kong, Jin Ang, Trlin Hamish John Francis, Wan Andrew, Yu Hanry, Domigan Laura Joy, Dobson Renwick Charles Joseph

机构信息

School of Biological Sciences, University of Canterbury, Christchurch, New Zealand.

Biomolecular Interaction Centre, University of Canterbury, Christchurch, New Zealand.

出版信息

Nat Food. 2025 Jan;6(1):25-30. doi: 10.1038/s43016-024-01085-9. Epub 2025 Jan 3.

DOI:10.1038/s43016-024-01085-9
PMID:39753758
Abstract

For commercial viability, cultivated meats require scientifically informed approaches to identify and manage hazards and risks. Here we discuss food safety in the rapidly developing field of cultivated meat as it shifts from lab-based to commercial scales. We focus on what science-informed risk mitigation processes can be implemented from neighbouring fields. We case-study pre-market safety assessments from UPSIDE Foods, GOOD Meat and Vow Group using publicly available dossiers. Quality control and safety assurance practices need to be established and standardized for cell lines and food-grade cell banks.

摘要

为了实现商业可行性，养殖肉类需要科学合理的方法来识别和管理危害与风险。在此，我们讨论养殖肉类这一快速发展领域中的食品安全问题，因为它正从实验室规模转向商业规模。我们关注可以从相邻领域实施哪些基于科学的风险缓解流程。我们使用公开档案对UPSIDE Foods、GOOD Meat和Vow Group的上市前安全评估进行案例研究。需要为细胞系和食品级细胞库建立并标准化质量控制和安全保证措施。

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引用本文的文献

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本文引用的文献

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Cell-based, cell-cultured, cell-cultivated, cultured, or cultivated. What is the best name for meat, poultry, and seafood made directly from the cells of animals?基于细胞的、细胞培养的、细胞培育的、培养的或培育的。直接由动物细胞制成的肉、禽和海鲜叫什么最合适？
NPJ Sci Food. 2023 Dec 6;7(1):62. doi: 10.1038/s41538-023-00234-x.
2
Cultured Meat Safety Research Priorities: Regulatory and Governmental Perspectives.cultured meat safety research priorities: regulatory and governmental perspectives. cultured meat safety research priorities: regulatory and governmental perspectives. cultured meat safety research priorities: regulatory and governmental perspectives. cultured meat safety research priorities: regulatory and governmental perspectives. cultured meat safety research priorities: regulatory and governmental perspectives. cultured meat safety research priorities: regulatory and governmental perspectives. cultured meat safety research priorities: regulatory and governmental perspectives. cultured meat safety research priorities: regulatory and governmental perspectives. cultured meat safety research priorities: regulatory and governmental perspectives. cultured meat safety research priorities: regulatory and governmental perspectives. cultured meat safety research priorities: regulatory and governmental 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The ghosts of HeLa: How cell line misidentification contaminates the scientific literature.海拉细胞的幽灵：细胞系错误鉴定如何污染科学文献。
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Bioinformatics and the allergy assessment of agricultural biotechnology products: industry practices and recommendations.生物信息学与农业生物技术产品的过敏评估：行业实践与建议。
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The application of post-market monitoring to novel foods.上市后监测在新型食品中的应用。
Food Chem Toxicol. 2008 Jan;46(1):9-33. doi: 10.1016/j.fct.2007.09.008. Epub 2007 Sep 14.
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Guidance on good cell culture practice. a report of the second ECVAM task force on good cell culture practice.良好细胞培养规范指南。欧洲替代方法验证中心良好细胞培养规范第二工作组报告。
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