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培养肉和海鲜产业的食品安全考虑因素和研究重点。

Food safety considerations and research priorities for the cultured meat and seafood industry.

机构信息

Vireo Advisors, LLC, Boston, Massachusetts, USA.

New Harvest Inc., Cambridge, Massachusetts, USA.

出版信息

Compr Rev Food Sci Food Saf. 2021 Nov;20(6):5421-5448. doi: 10.1111/1541-4337.12853. Epub 2021 Oct 10.

DOI:10.1111/1541-4337.12853
PMID:34633147
Abstract

Cell-cultured meat and seafood offer a sustainable opportunity to meet the world's increasing demand for protein in a climate-changed world. A responsible, data-driven approach to assess and demonstrate safety of cell-cultured meat and seafood can support consumer acceptance and help fully realize the potential of these products. As an initial step toward a thorough demonstration of safety, this review identifies hazards that could be introduced during manufacturing, evaluates applicability of existing safety assessment approaches, and highlights research priorities that could support safe commercialization. Input was gathered from members of the cultured meat and seafood industry, researchers, regulators, and food safety experts. A series of workshops were held with 87 industry representatives and researchers to create a modular manufacturing process diagram, which served as a framework to identify potential chemical and biological hazards along the steps of the manufacturing process that could affect the safety of a final food product. Interviews and feedback on draft documents validated the process diagram and supported hazard identification and evaluation of applicable safety methods. Most hazards are not expected to be novel; therefore, safety assessment methods from a range of fields, such as conventional and novel foods, foods produced from biotechnology, pharmaceuticals, and so forth, are likely to be applicable. However, additional assessment of novel inputs or products with significant differences from existing foods may be necessary. Further research on the safety of the inputs and associated residues, potential for contamination, and development of standardized safety assessment approaches (particularly animal-free methods) is recommended.

摘要

细胞培养肉和海鲜为在气候变化的世界中满足全球对蛋白质日益增长的需求提供了可持续的机会。采用负责任的、数据驱动的方法来评估和证明细胞培养肉和海鲜的安全性，可以支持消费者的接受度，并有助于充分发挥这些产品的潜力。作为全面展示安全性的初步步骤，本综述确定了在制造过程中可能引入的危害，评估了现有安全性评估方法的适用性，并强调了支持安全商业化的研究重点。意见来自培养肉和海鲜行业、研究人员、监管机构和食品安全专家的成员。与 87 名行业代表和研究人员举行了一系列研讨会，以创建一个模块化的制造工艺图，作为确定可能影响最终食品产品安全性的制造过程步骤中潜在化学和生物危害的框架。对草案文件的访谈和反馈验证了工艺图，并支持了危害识别和适用安全方法的评估。预计大多数危害不会是新出现的；因此，来自常规和新型食品、生物技术生产的食品、药品等多个领域的安全性评估方法可能适用。然而，可能需要对新型投入物或与现有食品有显著差异的产品进行额外的评估。建议进一步研究投入物及其相关残留物的安全性、潜在污染以及标准化安全性评估方法（特别是无动物方法）的开发。

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ACS Food Sci Technol. 2024 Dec 30;5(1):61-74. doi: 10.1021/acsfoodscitech.4c00281. eCollection 2025 Jan 17.
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Cell-Based Meat Safety and Regulatory Approaches: A Comprehensive Review.基于细胞的肉类安全性与监管方法：全面综述
Food Sci Anim Resour. 2025 Jan;45(1):145-164. doi: 10.5851/kosfa.2024.e122. Epub 2025 Jan 1.