普通人群中阻塞性睡眠呼吸暂停与高尿酸血症/痛风之间的关联：一项横断面研究。

Association between obstructive sleep apnea and hyperuricemia/gout in the general population: a cross-sectional study.

作者信息

Park Suyeon, Bak Seong-Hyeok, Kim Hyun-Sook, Lee Kyung-Ann

机构信息

Department of Biostatistics, Academic Research Office, Soonchunhyang University Seoul Hospital, Seoul, South Korea.

International Development and Cooperation, Graduate School of Multidisciplinary Studies Toward Future, Soonchunhyang University, Asan, South Korea.

出版信息

BMC Musculoskelet Disord. 2025 Jan 3;26(1):14. doi: 10.1186/s12891-024-08264-6.

DOI:10.1186/s12891-024-08264-6

PMID:39754080

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11697859/

Abstract

BACKGROUND

Obstructive sleep apnea (OSA) is linked to various health conditions, including cardiovascular diseases and metabolic disorders. Hyperuricemia and gout may be associated with OSA, but large-scale studies on this are limited. This study aimed to investigate the association between hyperuricemia/gout and OSA using data from the Korea National Health and Nutrition Survey (KNHANES).

METHODS

Using the 2019-2021 KNHANES data, 11,728 participants were selected. OSA risk was assessed using the STOP-BANG questionnaire score, which is as follows: (1) high-risk (5-8), (2) intermediate-risk (3-4), and (3) low-risk (0-2). Anthropometric, socioeconomic, health-related variables, and biochemical measurements, including serum uric acid (SUA) levels, were included in the analysis. Multiple regression analyses examined the association between the STOP-BANG score and hyperuricemia/gout.

RESULTS

After assigning weights, among 25,354,276 individuals, 3,114,119 (12.2%) had a high OSA risk. The high OSA risk group exhibited higher SUA levels (5.9 mg/dL) than those of the intermediate (5.6 mg/dL) and low OSA risk groups (4.7 mg/dL) (P < 0.001). Additionally, it had a higher incidence of physician-diagnosed gout than the other groups (6.6% vs. 3.8% vs. 0.8%, respectively, P < 0.001). The STOP-BANG questionnaire scores and SUA levels were positively correlated (r = 0.383; P < 0.001). When adjusted for confounding factors, the high OSA risk group demonstrated an association with hyperuricemia (SUA ≥ 6.8 mg/d) (adjusted Odds Ratio [OR]: 1.462, 95% Confidence interval [CI]: 1.108-1.929). High and intermediate OSA risk was associated with severe hyperuricemia (SUA ≥ 9.0 mg/dL) and gout; however, the significant association between OSA and severe hyperuricemia and gout attenuated to null after adjusting for confounding factors.

CONCLUSIONS

High OSA risk was independently associated with hyperuricemia but not severe hyperuricemia or gout. Screening and management of OSA may help prevent hyperuricemia.

摘要

背景

阻塞性睡眠呼吸暂停（OSA）与多种健康状况相关，包括心血管疾病和代谢紊乱。高尿酸血症和痛风可能与OSA有关，但对此的大规模研究有限。本研究旨在利用韩国国家健康与营养调查（KNHANES）的数据，调查高尿酸血症/痛风与OSA之间的关联。

方法

使用2019 - 2021年KNHANES数据，选取了11728名参与者。使用STOP - BANG问卷评分评估OSA风险，如下：（1）高风险（5 - 8分），（2）中度风险（3 - 4分），（3）低风险（0 - 2分）。分析纳入了人体测量学、社会经济、健康相关变量以及生化测量指标，包括血清尿酸（SUA）水平。多元回归分析检验了STOP - BANG评分与高尿酸血症/痛风之间的关联。

结果

加权后，在25354276名个体中，3114119名（12.2%）有高OSA风险。高OSA风险组的SUA水平（5.9毫克/分升）高于中度（5.6毫克/分升）和低OSA风险组（4.7毫克/分升）（P < 0.001）。此外，其医生诊断痛风的发生率高于其他组（分别为6.6%、3.8%和0.8%，P < 0.001）。STOP - BANG问卷评分与SUA水平呈正相关（r = 0.383；P < 0.001）。在调整混杂因素后，高OSA风险组与高尿酸血症（SUA≥6.8毫克/分升）相关（调整后的优势比[OR]：1.462，95%置信区间[CI]：1.108 - 1.929）。高和中度OSA风险与严重高尿酸血症（SUA≥9.0毫克/分升）和痛风相关；然而，在调整混杂因素后，OSA与严重高尿酸血症和痛风之间的显著关联减弱至无关联。