Mahdavi Valeh, Kazerani Hamid Reza, Taghizad Fereidoun, Balaei Hedyeh
Department of Basic Sciences, Faculty of Veterinary Medicine, Ferdowsi University of Mashhad, Mashhad, Iran.
Lipids Health Dis. 2025 Jan 4;24(1):3. doi: 10.1186/s12944-024-02423-3.
Obesity can arise from various physiological disorders. This research examined the impacts of the bacteriocin, gassericin A, which is generated by certain gut bacteria, using an in vivo model of obesity.
Fifty Swiss NIH mice were randomly assigned to five different groups. One group was given a standard diet, while the remaining groups were fed a diet high in fat and sugar. The test groups received gassericin A at doses of 0.75, 1.5, or 3 mIU/kg through intraperitoneal injection, daily for 10 weeks. Body weight, fasting blood sugar, serum lipid profile, and hepatic function indicators were then assessed. Additionally, the blood profile, markers of oxidative stress, and expression levels of specific genes associated with obesity, Zfp423, and Fabp4, were evaluated in abdominal adipose tissue.
A high-calorie diet negatively impacted abdominal fat, serum cholesterol, LDL, and hepatic enzymes. However, gassericin A significantly improved these effects, despite increasing weight gain and abdominal fat. Furthermore, it improved redox status, downregulated the Zfp423 gene, and enhanced the expression of the Fabp4 gene. Finally, the bacteriocin caused thrombocytopenia and mild decreases in erythrocytes, hematocrit, and hemoglobin levels.
These results suggest that, despite causing weight gain, gassericin A may improve obesity-related complications.
肥胖可由多种生理紊乱引起。本研究使用肥胖的体内模型，研究了某些肠道细菌产生的细菌素加塞里辛A的影响。
将50只瑞士NIH小鼠随机分为五组。一组给予标准饮食，其余组给予高脂肪和高糖饮食。测试组通过腹腔注射，每天给予剂量为0.75、1.5或3 mIU/kg的加塞里辛A，持续10周。然后评估体重、空腹血糖、血脂谱和肝功能指标。此外，还评估了腹部脂肪组织中的血液指标、氧化应激标志物以及与肥胖相关的特定基因Zfp423和Fabp4的表达水平。
高热量饮食对腹部脂肪、血清胆固醇、低密度脂蛋白和肝酶产生负面影响。然而，尽管加塞里辛A增加了体重增加和腹部脂肪，但它显著改善了这些影响。此外，它改善了氧化还原状态，下调了Zfp423基因，并增强了Fabp4基因的表达。最后，细菌素导致血小板减少以及红细胞、血细胞比容和血红蛋白水平轻度下降。
这些结果表明，尽管加塞里辛A会导致体重增加，但它可能改善与肥胖相关的并发症。
