Musazadeh Vali, Roshanravan Neda, Dehghan Parvin, Ahrabi Sana Sedgh
Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran.
Department of Community Nutrition, School of Nutrition and Food Science, Tabriz University of Medical Sciences, Tabriz, Iran.
Front Nutr. 2022 May 23;9:844242. doi: 10.3389/fnut.2022.844242. eCollection 2022.
Non-alcoholic fatty liver disease (NAFLD) has become prevalent in recent decades, especially in developed countries; yet the approaches for preventing and treating NAFLD are not clear. This study aimed to summarize meta-analyses of randomized controlled trials that examined the effects of probiotics on NAFLD. We systematically searched PubMed, Scopus, Embase, Web of Science, and Cochrane Central Library databases up to August 2021. All Meta-analysis studies assessing the effect of probiotics on liver function tests [alanine aminotransferase (ALT), aspartate aminotransferase (AST), and Gamma-glutamyl transferase (GGT)] were included. Meta-analysis was conducted using a random-effects model. Sensitivity and subgroup analyses were also performed. The umbrella study covered ten eligible studies involving 5,162 individuals. Beneficial effects of probiotics supplementation were revealed on ALT (ES = -10.54 IU/L; 95% CI: -12.70, -8.39; < 0.001; = 60.9%, = 0.006), AST (ES = -10.19 IU/L, 95%CI: -13.08, -7.29, < 0.001; = 79.8%, < 0.001), and GGT (ES = -5.88 IU/L, 95% CI: -7.09, -4.67, = 0.009; = 0.0%, = 0.591) levels. Probiotics have ameliorating effects on ALT, AST, and GGT levels in patients with NAFLD. Overall, Probiotics could be recommended as an adjuvant therapeutic method for the management of NAFLD.
非酒精性脂肪性肝病（NAFLD）在近几十年中变得普遍，尤其是在发达国家；然而，预防和治疗NAFLD的方法尚不清楚。本研究旨在总结对益生菌治疗NAFLD效果进行检验的随机对照试验的荟萃分析。我们系统检索了截至2021年8月的PubMed、Scopus、Embase、Web of Science和Cochrane Central Library数据库。纳入所有评估益生菌对肝功能检查[丙氨酸转氨酶（ALT）、天冬氨酸转氨酶（AST）和γ-谷氨酰转移酶（GGT）]影响的荟萃分析研究。采用随机效应模型进行荟萃分析。还进行了敏感性和亚组分析。本伞状研究涵盖了10项符合条件的研究，涉及5162名个体。结果显示补充益生菌对ALT（效应量ES = -10.54 IU/L；95%置信区间：-12.70，-8.39；P < 0.001；I² = 60.9%，P = 0.006）、AST（ES = -10.19 IU/L，95%置信区间：-13.08，-7.29，P < 0.001；I² = 79.8%，P < 0.001）和GGT（ES = -5.88 IU/L，95%置信区间：-7.09，-4.67，P = 0.009；I² = 0.0%，P = 0.591）水平有有益影响。益生菌对NAFLD患者的ALT、AST和GGT水平有改善作用。总体而言，益生菌可被推荐作为NAFLD管理的辅助治疗方法。
