Biewenga W J, Van den Brom W E
Res Vet Sci. 1985 Jan;38(1):1-5.
In 30 clinically healthy dogs (weights 7.5 to 57 kg) and in 41 proteinuric dogs the 131I-hippuran blood disappearance curve after single injection was determined (0 to 90 minutes), described by a bi-exponential function and analysed according to a two compartment model. The dependence of the blood clearance (C), representing an effective renal blood flow, on the bodyweight (W) (kg) could be described with both a linear function (C = 61 + 13.2 W ml min-1) and a power function (C = 30.56 W0.79 ml min-1) in the healthy dogs. The results of the regression between blood clearance and bodyweight were reproducible (r = 0.92, n = 10 residual error 12 per cent, P less than 0.01).
在30只临床健康犬（体重7.5至57千克）和41只蛋白尿犬中，单次注射后测定了131I - 马尿酸的血液消失曲线（0至90分钟），该曲线由双指数函数描述，并根据两室模型进行分析。在健康犬中，代表有效肾血流量的血液清除率（C）与体重（W）（千克）的关系可用线性函数（C = 61 + 13.2W毫升/分钟）和幂函数（C = 30.56W^0.79毫升/分钟）来描述。血液清除率与体重之间回归分析的结果具有可重复性（r = 0.92，n = 10，残余误差12%，P < 0.01）。
