Deprato Andy, Garud Arundhati, Azzolina Danila, Murgia Nicola, Davenport Margie H, Kaul Padma, Lacy Paige, Moitra Subhabrata
Michael G. DeGroote School of Medicine, McMaster University, Hamilton, Ontario, Canada; Alberta Respiratory Centre, Division of Pulmonary Medicine, Department of Medicine, University of Alberta, Edmonton, Alberta, Canada.
Bagchi School of Public Health, Ahmedabad University, Ahmedabad, India.
J Hazard Mater. 2025 Mar 15;486:137028. doi: 10.1016/j.jhazmat.2024.137028. Epub 2024 Dec 26.
Despite numerous studies linking prenatal vaping to adverse perinatal outcomes, a systematic assessment for critical comparison remains absent. To investigate these associations, we conducted a systematic search of studies assessing perinatal outcomes in mothers and/or neonates exposed to vaping during pregnancy compared to those in women without prenatal vaping exposure through MEDLINE, EMBASE, Scopus, Web of Science, Cochrane Library, PROSPERO, and Google Scholar until July 5, 2024. We performed inverse-variance random-effects meta-analyses for maternal and neonatal outcomes of 23 studies with a total of 924,376 participants with 7552 reporting vaping-only use during pregnancy. Prenatal vaping was associated with 53 % higher odds of an adverse maternal outcome (OR: 1.53; 95 % CI: 1.27-1.85; I = 80 %), particularly with decreased breastfeeding (OR: 0.53; 95 % CI: 0.38-0.72; I = 45 %) and reduced prevalence of adequate prenatal care (OR: 0.69; 95 % CI: 0.56-0.86; I = 82 %). Prenatal vaping was also associated with a similarly 53 % higher odds of an adverse neonatal outcome (OR: 1.53; 95 % CI: 1.34-1.76; I = 45 %), such as low birth weight (OR: 1.56; 95 % CI: 1.28-1.93; I: 15 %), preterm birth (OR: 1.49; 955 CI: 1.27-1.76; I: 0 %), and small for gestational age (OR: 1.48; 955 CI: 1.16-1.89; I: 70 %). This is the first comprehensive systematic review and meta-analysis demonstrating vaping during pregnancy as a risk factor for increased odds of both maternal and neonatal outcomes and underscores the urgency to address awareness and regulations of vaping and its potential harms to both humans and the environment. REGISTRATION: PROSPERO CRD42023446266.
尽管有大量研究将产前吸电子烟与不良围产期结局联系起来，但仍缺乏用于关键比较的系统评估。为了调查这些关联，我们通过MEDLINE、EMBASE、Scopus、Web of Science、Cochrane图书馆、PROSPERO和谷歌学术搜索，对评估孕期接触电子烟的母亲和/或新生儿与未接触产前电子烟的女性的围产期结局的研究进行了系统检索，检索截至2024年7月5日。我们对23项研究的孕产妇和新生儿结局进行了逆方差随机效应荟萃分析，共有924376名参与者，其中7552人报告孕期仅吸电子烟。产前吸电子烟与孕产妇不良结局的几率高53%相关（OR：1.53；95%CI：1.27 - 1.85；I² = 80%），特别是母乳喂养减少（OR：0.53；95%CI：0.38 - 0.72；I² = 45%）和充分产前护理的患病率降低（OR：0.69；95%CI：0.56 - 0.86；I² = 82%）。产前吸电子烟还与新生儿不良结局的几率同样高53%相关（OR：1.53；95%CI：1.34 - 1.76；I² = 45%），如低出生体重（OR：1.56；95%CI：1.28 - 1.93；I²：15%）、早产（OR：1.49；95%CI：1.27 - 1.76；I²：0%）和小于胎龄（OR：1.48；95%CI：1.16 - 1.89；I²：70%）。这是第一项全面的系统评价和荟萃分析，证明孕期吸电子烟是孕产妇和新生儿结局几率增加的危险因素，并强调了提高对吸电子烟及其对人类和环境潜在危害的认识和监管的紧迫性。注册信息：PROSPERO CRD42023446266。
