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灵长类动物神经发生的局限性。

Limits of neurogenesis in primates.

作者信息

Rakic P

出版信息

Science. 1985 Mar 1;227(4690):1054-6. doi: 10.1126/science.3975601.

DOI:10.1126/science.3975601
PMID:3975601
Abstract

Systematic analysis of autoradiograms prepared from postpubertal rhesus monkeys given single and multiple injections of tritium-labeled thymidine and killed 3 days to 6 years later displayed a slow turnover of glial cells but failed to reveal any radiolabeled neurons. Therefore, unlike neurons of some nonprimate species, all neurons of the rhesus monkey brain are generated during prenatal and early postnatal life. A stable population of neurons in primates, including humans, may be important for the continuity of learning and memory over a lifetime.

摘要

对青春期后恒河猴进行单次和多次注射氚标记胸腺嘧啶核苷,并在3天至6年后处死,对制备的放射自显影片进行系统分析,结果显示神经胶质细胞更新缓慢,但未发现任何放射性标记的神经元。因此,与一些非灵长类物种的神经元不同,恒河猴大脑的所有神经元都是在产前和产后早期生成的。包括人类在内的灵长类动物中稳定的神经元群体,可能对一生的学习和记忆的连续性很重要。

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