Extended homogeneous field correction method based on oblique projection in OPM-MEG.

Optically pumped magnetometer-based magnetoencephalography (OPM-MEG) is an novel non-invasive functional imaging technique that features more flexible sensor configurations and wearability; however, this also increases the requirement for environmental noise suppression. Subspace projection algorithms are widely used in MEG to suppress noise. However, in OPM-MEG systems with a limited number of channels, subspace projection methods that rely on spatial oversampling exhibit reduced performance. The homogeneous field correction (HFC) method resolves this problem by constructing a low-rank spatial model; however, it cannot address complex non-homogeneous noise. The spatiotemporal extended homogeneous field correction (teHFC) method uses multiple orthogonal projections to suppress disturbances. However, the signal and noise subspace are not completely orthogonal, limiting enhancement in the capabilities of the teHFC. Therefore, we propose an extended homogeneous field correction method based on oblique projection (opHFC), which overcomes the issue of non-orthogonality between the signal and noise subspace, enhancing the ability to suppress complex interferences. The opHFC constructs an oblique projection operator that divides the signals into internal and external components, eliminating complex interferences through temporal extension. We compared the opHFC with four benchmark methods by simulations and auditory and somatosensory evoked OPM-MEG experiments. The results demonstrate that opHFC provides superior noise suppression with minimal distortion, enhancing the signal quality at the sensor and source levels. Our method offers a novel approach to reducing interference in OPM-MEG systems, expanding their application scenarios, and providing high-quality signals for scientific research and clinical applications based on OPM-MEG.