Khadem Sadigh M, Sayyar Z, Mohammadi M A, Baharlounezhad F
Department of Laser and Optics engineering, University of Bonab, Bonab, Iran.
Department of Chemical Engineering, University of Bonab, Bonab, Iran.
Int J Biol Macromol. 2025 Mar;294:139407. doi: 10.1016/j.ijbiomac.2024.139407. Epub 2025 Jan 3.
Today, curcumin's therapeutic properties are used in drug delivery systems. In this work, chitosan (CS) /Montmorillonite (MMT) hydrogels were synthesized to improve the performance of curcumin molecules. According to the results, drug release characteristics of CS/MMT/curcumin highly depend on the pH of the environment and properties of Ag nanoparticles. Moreover, curcumin and Ag nanoparticles were placed under the influence of oxygen plasma. Our results indicate that oxygen plasma, as a simple, clean, and environment-friendly method, can be used as an effective method for controlling the efficiency of drug release and antibacterial characteristics of curcumin molecules in hydrogels. In this case, by increasing the exposure time of the samples under the influence of oxygen plasma, their antibacterial properties and drug release efficiency are significantly enhanced.
如今，姜黄素的治疗特性被应用于药物递送系统。在这项工作中，合成了壳聚糖（CS）/蒙脱石（MMT）水凝胶以改善姜黄素分子的性能。根据结果，CS/MMT/姜黄素的药物释放特性高度依赖于环境的pH值和银纳米颗粒的性质。此外，姜黄素和银纳米颗粒受到氧等离子体的影响。我们的结果表明，氧等离子体作为一种简单、清洁且环保的方法，可作为控制水凝胶中姜黄素分子药物释放效率和抗菌特性的有效方法。在这种情况下，通过增加样品在氧等离子体影响下的暴露时间，其抗菌性能和药物释放效率显著提高。
