Efficacy of Fractional 2940-nm Erbium:YAG Laser Combined with Platelet-Rich Plasma Versus its Combination with Low-Level Laser Therapy for Scar Revision.

OBJECTIVE

We sought to compare the safety and efficacy of combining fractional 2940-nm Erbium:YAG (Er:YAG) laser with autologous platelet-rich plasma (PRP) versus its combination with low-level laser therapy (LLLT) for enhancing the outcome of postsurgical and post-traumatic scars.

METHODS

Fourty-five individuals with post-surgical or post-traumatic scars were randomly divided into three groups: Group A received four fractional Er:YAG laser sessions spaced four weeks apart along with eight sessions of intradermal PRP injections spaced two weeks apart; Group B received four fractional Er:YAG laser sessions spaced four weeks apart along with two sessions of light emitting diode (LED) weekly; and Group C received four fractional Er:YAG laser sessions spaced four weeks apart. Treatment efficacy was evaluated using clinical photographs, Vancouver Scar Scale (VSS), patient satisfaction and histopathology.

RESULTS

Regarding vascularity following treatment and the total VSS score, there were significant differences between the studied groups, with scoring was the lowest in Group A compared to Group B and C. Patient satisfaction was the highest in Group A compared to Group B and C.

LIMITATIONS

A limitation of the current study is the short follow-up period.

CONCLUSION

Scar revision therapy using combined fractional Er:YAG laser with either PRP or LLLT were found to be more efficient and superior to fractional Er:YAG laser alone.