Department of Dermatology, Alexandria University, Alexandria, Egypt.
Department Unit, Department of Medical Application of Lasers (MAL), National Institute of Laser Sciences, Cairo, Egypt.
J Dermatolog Treat. 2021 Dec;32(8):965-972. doi: 10.1080/09546634.2020.1729334. Epub 2020 Apr 2.
Different modalities have been tried for treating atrophic post traumatic scars.
To compare the efficacy of microneedling combined with PRP with that of fractional erbium-doped yttrium aluminum garnet (Er: YAG) laser in treating post-traumatic atrophic scars.
Forty-five patients with atrophic post traumatic scars were subdivided into three groups. Group I was subjected to four sessions of skin microneedling followed by topical application of platelet-rich plasma (PRP) immediately after each session. Group II was subjected to the same protocol of treatment but for six sessions. Group III was subjected to four sessions of fractional Er: YAG laser at 4 weeks intervals for four sessions. Response to treatment was assessed clinically using the Quartile Grading Scale and histopathologically using H&E stain, trichrome and Orcein special stains.
All patients showed significant clinical improvement regardless of the treatment. There was a significant difference in clinical and histopathological improvement between groups I and III, but there was no significant difference in improvement neither between groups I and II nor between groups II and III.
microneedling could be as effective as a fractional laser when combined with PRP and when used for more sessions.
已经尝试了不同的方法来治疗萎缩性创伤后疤痕。
比较微针联合 PRP 与铒石榴石激光（Er：YAG）治疗外伤性萎缩性疤痕的疗效。
将 45 例萎缩性创伤后疤痕患者分为三组。第 I 组接受 4 次皮肤微针治疗，每次治疗后立即局部应用富血小板血浆（PRP）。第 II 组接受相同的治疗方案，但治疗 6 次。第 III 组在 4 周间隔内接受 4 次分段铒：YAG 激光治疗。使用四分位等级量表进行临床评估，使用 H&E 染色、三色和奥塞尔特殊染色进行组织病理学评估。
所有患者无论接受何种治疗均显示出明显的临床改善。第 I 组和第 III 组在临床和组织病理学改善方面有显著差异，但第 I 组和第 II 组之间以及第 II 组和第 III 组之间的改善均无显著差异。
微针联合 PRP 治疗时，可与分段激光一样有效，且治疗次数更多。
