[具体药物名称]在大鼠急性血栓形成模型中的抗血栓作用：对内皮黏附分子和炎症因子的调节
Antithrombic effects of in a rat model of acute thrombosis: modulation of endothelial adhesion molecules and inflammatory factors.
作者信息
Jo Seon Ha, Park Soo-Yeon, Lee Jinhee, Gwon Yuri, Kim Ji Yeon
机构信息
Department of Food Science and Biotechnology, Seoul National University of Science and Technology, 232, Gongneung-ro, Nowon-gu, Seoul, 01811 Republic of Korea.
Global Leaders College, Yonsei University, 50 Yonsei-ro, Seodaemun-gu, Seoul, 03722 Republic of Korea.
出版信息
Food Sci Biotechnol. 2024 Jun 28;34(1):269-276. doi: 10.1007/s10068-024-01625-w. eCollection 2025 Jan.
(PR) is a tropical plant used as a spice in Southeast Asia. This study investigated the antithrombotic effect of PR in rats with acute thrombosis induced by collagen and epinephrine (CE). The rats were divided into four groups, control (CON), CE, PR15, and PR30, with PR administered at 15 and 30 mg/kg body weight. PR treatment significantly reduced paralysis time compared to the CE. The activated partial thromboplastin time in the PR15 group tended to decrease compared to the CE. Histologically, the both sample groups exhibited reduced blood clots within lung tissues and decreased E-selectin expression in aortic tissue. PR also tended to decrease cyclooxygenase levels and significantly reduce intracellular adhesion molecule 1 levels. PR has demonstrated potential for inhibiting thrombosis by regulating coagulation factors, adhesion molecules, and cyclooxygenase. This finding suggests its potential application as a therapeutic agent for lowering the risk of cardiovascular diseases.
PR是一种在东南亚用作香料的热带植物。本研究调查了PR对胶原蛋白和肾上腺素（CE）诱导的急性血栓形成大鼠的抗血栓作用。大鼠分为四组，对照组（CON）、CE组、PR15组和PR30组，PR以15和30mg/kg体重给药。与CE组相比，PR治疗显著缩短了瘫痪时间。与CE组相比，PR15组的活化部分凝血活酶时间有下降趋势。组织学上，两个样本组的肺组织内血栓均减少，主动脉组织中E-选择素表达降低。PR也有降低环氧合酶水平的趋势，并显著降低细胞间黏附分子1水平。PR已显示出通过调节凝血因子、黏附分子和环氧合酶来抑制血栓形成的潜力。这一发现表明其作为降低心血管疾病风险的治疗药物的潜在应用价值。
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