Key Laboratory of Modern Preparation of TCM, Ministry of Education, Jiangxi University of Chinese Medicine, Nanchang 330004, Jiangxi, China.
Murad Research Center for Modernized Chinese Medicine, Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
Adv Drug Deliv Rev. 2021 Nov;178:113964. doi: 10.1016/j.addr.2021.113964. Epub 2021 Sep 6.
Traditional herbal medicine (THM), an ancient science, is a gift from nature. For thousands of years, it has helped humans fight diseases and protect life, health, and reproduction. Nanomedicine, a newer discipline has evolved from exploitation of the unique nanoscale morphology and is widely used in diagnosis, imaging, drug delivery, and other biomedical fields. Although THM and nanomedicine differ greatly in time span and discipline dimensions, they are closely related and are even evolving toward integration and convergence. This review begins with the history and latest research progress of THM and nanomedicine, expounding their respective developmental trajectory. It then discusses the overlapping connectivity and relevance of the two fields, including nanoaggregates generated in herbal medicine decoctions, the application of nanotechnology in the delivery and treatment of natural active ingredients, and the influence of physiological regulatory capability of THM on the in vivo fate of nanoparticles. Finally, future development trends, challenges, and research directions are discussed.
传统草药（THM）是一门古老的科学，是大自然的馈赠。几千年来，它帮助人类对抗疾病，保护生命、健康和生殖。纳米医学是一门新兴学科，它源于对独特纳米级形态的利用，广泛应用于诊断、成像、药物输送和其他生物医学领域。尽管 THM 和纳米医学在时间跨度和学科维度上有很大的不同，但它们密切相关，甚至正在朝着整合和融合的方向发展。本综述首先介绍了 THM 和纳米医学的历史和最新研究进展，阐述了它们各自的发展轨迹。然后讨论了这两个领域的重叠连接和相关性，包括草药汤中产生的纳米聚集体、纳米技术在天然活性成分的输送和治疗中的应用，以及 THM 的生理调节能力对体内纳米粒子命运的影响。最后，讨论了未来的发展趋势、挑战和研究方向。
