Li Feng, Zheng Rongrong, Yan Jun, Zhang Zhongdong, Liu Hong, Shi Jinchuan
The Second Infectious Disease Department, Xixi Hospital of Hangzhou, Hangzhou, China.
Department of pathology, Xixi Hospital of Hangzhou, Hangzhou, China.
Front Oncol. 2024 Dec 20;14:1462381. doi: 10.3389/fonc.2024.1462381. eCollection 2024.
Kaposi's sarcoma (KS) is a soft tissue lesion that resembles a hyperpigmented angiosarcoma and is typically associated with human herpesvirus 8 (HHV-8) infection. It is most frequently observed in immunocompromised patients, particularly those with AIDS, and is also referred to as HIV-associated Kaposi's sarcoma (AIDS-KS). The disease progresses rapidly, is challenging to manage, and has a high mortality rate. This case report presents a patient with AIDS-KS who experienced relapse after chemotherapy with anthracyclines. Subsequent chemotherapy with the same method had no significant effect. However, complete remission was achieved after the addition of a programmed cell death protein 1(PD-1) inhibitor, as confirmed by pathological biopsy. The PD-1 inhibitor was well-tolerated and had few adverse effects. It also helped to improve the immune reconstitution of the patient. The report highlights the remarkable efficacy of the PD-1 inhibitor in treating AIDS-KS. This provides case support for PD-1 inhibitors for AIDS-KS.
卡波西肉瘤（KS）是一种软组织病变，类似于色素沉着性血管肉瘤，通常与人类疱疹病毒8（HHV-8）感染有关。它最常见于免疫功能低下的患者，尤其是艾滋病患者，也被称为HIV相关卡波西肉瘤（AIDS-KS）。该疾病进展迅速，治疗具有挑战性，死亡率很高。本病例报告介绍了一名AIDS-KS患者，其在接受蒽环类药物化疗后复发。随后采用相同方法进行化疗无明显效果。然而，在添加程序性细胞死亡蛋白1（PD-1）抑制剂后实现了完全缓解，病理活检证实了这一点。PD-1抑制剂耐受性良好，不良反应很少。它还有助于改善患者的免疫重建。该报告强调了PD-1抑制剂在治疗AIDS-KS方面的显著疗效。这为PD-1抑制剂治疗AIDS-KS提供了病例支持。
