Pu Lingling, Wang Yonghui, Pang Wei, Wei Jingyu, Wu Jianquan, Guo Changjiang
Tianjin Institute of Environmental and Operational Medicine, Tianjin, 300050, China.
Heliyon. 2024 Dec 9;10(24):e41056. doi: 10.1016/j.heliyon.2024.e41056. eCollection 2024 Dec 30.
The human trial aimed to study the influence of propolis on immune function in the elderly.
Non-institutionalized community-dwelling individuals aged 60-80 years were recruited from Tianjin, China. Participants were assigned randomly to either the Chinese propolis group (600 mg/day, n = 32) or the control group (n = 30). Serum antibodies and biochemical indices were measured using commercial kits; cytokines were detected using ELISA assay, and the functions of lymphocytes and neutrophils were assayed using the MTT and methods, respectively. A dietary survey was conducted based on 24-h recall.
The study lasted for 12 weeks. Immunoglobulin G (IgG) levels notably increased at week 6 although these levels returned to baseline by week 12 in the Chinese propolis group. No significant difference was detected in serum antibodies, cytokines, or lymphocyte and neutrophil functions between the two groups at any time point.
Chinese propolis could stimulate IgG secretion within a certain period, but it was restored to baseline levels over time. Propolis does not significantly affect other immune markers in the elderly.
该人体试验旨在研究蜂胶对老年人免疫功能的影响。
从中国天津招募60 - 80岁非机构化居住在社区的个体。参与者被随机分为中华蜂胶组（600毫克/天，n = 32）或对照组（n = 30）。使用商用试剂盒测量血清抗体和生化指标；使用酶联免疫吸附测定法检测细胞因子，分别使用MTT法和[此处原文缺失具体方法]检测淋巴细胞和中性粒细胞的功能。基于24小时回顾进行饮食调查。
该研究持续了12周。中华蜂胶组在第6周时免疫球蛋白G（IgG）水平显著升高，不过到第12周时这些水平恢复到基线。在任何时间点，两组之间的血清抗体、细胞因子或淋巴细胞和中性粒细胞功能均未检测到显著差异。
中华蜂胶在一定时期内可刺激IgG分泌，但随时间推移会恢复到基线水平。蜂胶对老年人的其他免疫标志物无显著影响。
