氯化钴对丁基羟基甲苯诱导的大鼠肝坏死的影响。

Effect of cobaltous chloride on butylated hydroxytoluene-induced hepatic necrosis in rats.

作者信息

Nakagawa Y, Tayama K, Nakao T, Hiraga K

出版信息

Toxicol Lett. 1985 Jan;24(1):85-9. doi: 10.1016/0378-4274(85)90144-4.

Abstract

Although a single dose of butylated hydroxytoluene (BHT); 1000 mg/kg to rats induced a hepatic injury accompanying centrilobular necrosis, the pretreatment with cobaltous chloride, an inhibitor of cytochrome P-450 synthesis, could inhibit the damage. The marked elevations of serum transaminase activities and bile acid content induced by BHT were diminished to nearly the control level by pretreatment with cobaltous chloride. The protective effect of cobaltous chloride on BHT-induced hepatotoxicity is discussed.

摘要

尽管给大鼠单次注射1000毫克/千克的丁基羟基甲苯（BHT）会导致伴有小叶中心坏死的肝损伤，但用细胞色素P - 450合成抑制剂氯化钴进行预处理可以抑制这种损伤。BHT诱导的血清转氨酶活性和胆汁酸含量的显著升高通过氯化钴预处理降低到几乎对照水平。讨论了氯化钴对BHT诱导的肝毒性的保护作用。