Wang Zitong, Zhao Feng, Lang Hongxin, Ren Haiyue, Zhang Qiqi, Huang Xing, He Cai, Xu Chengcheng, Tan Chiyu, Ma Jiajie, Duan Shu, Wang Zhe
Department of Pathology, Shengjing Hospital of China Medical University, No. 36 Sanhao Street, Shenyang, Liaoning 110004, China.
Department of Stem Cells and Regenerative Medicine, Shenyang Key Laboratory of Stem Cell and Regenerative Medicine, China Medical University, No. 77 Puhe Road, Shenyang, Liaoning 110013, China.
Burns Trauma. 2025 Jan 3;13:tkae077. doi: 10.1093/burnst/tkae077. eCollection 2025.
Stem cells (SCs) can self-replicate and differentiate into multiple lineages. Organoids, 3D cultures derived from SCs, can replicate the spatial structure and physiological characteristics of organs . Skin organoids can effectively simulate the physiological structure and function of skin tissue, reliably restoring the natural skin ecology in various environments. Skin organoids have been employed extensively in skin development and pathology research, offering valuable insights for drug screening. Moreover, they play crucial roles in skin regeneration and tissue repair. This in-depth review explores the construction and applications of skin organoids in wound healing, with a focus on their construction process, including skin appendage integration, and significant advancements in wound-healing research.
干细胞（SCs）能够自我复制并分化为多种细胞谱系。类器官是由干细胞衍生而来的三维培养物，能够复制器官的空间结构和生理特征。皮肤类器官可以有效地模拟皮肤组织的生理结构和功能，在各种环境中可靠地恢复自然皮肤生态。皮肤类器官已广泛应用于皮肤发育和病理学研究，为药物筛选提供了有价值的见解。此外，它们在皮肤再生和组织修复中发挥着关键作用。这篇深度综述探讨了皮肤类器官在伤口愈合中的构建和应用，重点关注其构建过程，包括皮肤附属器整合，以及伤口愈合研究的重大进展。
