Er Besir
Department of Biology, Faculty of Science, Firat University, Elazig 23100, Türkiye.
Prev Nutr Food Sci. 2024 Dec 31;29(4):405-413. doi: 10.3746/pnf.2024.29.4.405.
Magnesium (Mg) is a mineral necessary for many biological activities in mammals. Here, we compared the effect of two Mg compounds [Mg picolinate (MgPic) to Mg oxide (MgO)] on Mg bioavailability and intestinal Mg and calcium transporter protein levels. Three groups of 21 male Wistar-Albino rats were randomly allocated and fed a standard diet (control) or a 500 mg/kg Mg-supplemented (MgPic or MgO) diet for 8 weeks. The serum and liver Mg levels, Mg absorptivity, and retentivity were augmented in the MgPic group compared with the MgO group (<0.05). Only MgPic supplementation elevated the expression of the genes encoding CLDN2, CLDN15, CNNM4, NCX1, PMCA1b, NCX2, and Calbindin-D9k in the jejunum by 1.59, 1.58, 1.70, 1.82, 2.02, 2.03, and 2.31 fold, respectively (<0.05). Compared to the MgO-fed rats, MgPic rats had higher expression of the genes encoding NCX1, NCX2, PMCA1b, and Calbindin-D9k in the jejunum by 1.43, 1.72, 1.54, and 1.69 fold, respectively (<0.01). These results suggest that MgPic increases Mg absorptivity and retentivity more than Mg bioavailability. In addition, MgPic can improve the paracellular and transcellular cationic mineral transport process. Thus, Mg deficiency disorders might be alleviated by MgPic more effectively than MgO.
镁（Mg）是哺乳动物许多生物活动所必需的一种矿物质。在此，我们比较了两种镁化合物[吡啶甲酸镁（MgPic）和氧化镁（MgO）]对镁生物利用度以及肠道镁和钙转运蛋白水平的影响。将三组21只雄性Wistar - 白化大鼠随机分组，分别喂食标准饮食（对照组）或添加500 mg/kg镁（MgPic或MgO）的饮食，持续8周。与MgO组相比，MgPic组的血清和肝脏镁水平、镁吸收率和保留率均有所提高（<0.05）。仅补充MgPic可使空肠中编码CLDN2、CLDN15、CNNM4、NCX1、PMCA1b、NCX2和钙结合蛋白 - D9k的基因表达分别增加1.59、1.58、1.70、1.82、2.02、2.03和2.31倍（<0.05）。与喂食MgO的大鼠相比，MgPic组大鼠空肠中编码NCX1、NCX2、PMCA1b和钙结合蛋白 - D9k的基因表达分别高1.43、1.72、1.54和1.69倍（<0.01）。这些结果表明，MgPic比MgO更能提高镁的吸收率和保留率。此外，MgPic可改善细胞旁和跨细胞阳离子矿物质转运过程。因此，MgPic可能比MgO更有效地缓解镁缺乏症。
