Elbanna Ahmed H, Kou Xinhui, Prajapati Dilip V, Rakshit Surasree, Butcher Rebecca A
Department of Chemistry, University of Florida, Gainesville, FL, 32611, USA.
Department of Pharmacognosy, Faculty of Pharmacy, Cairo University, Cairo, 11562, Egypt.
Nat Prod Bioprospect. 2025 Jan 6;15(1):10. doi: 10.1007/s13659-024-00490-8.
The euglenatides are a family of hybrid polyketide-nonribosomal peptides produced by the unicellular algae Euglena gracilis. These compounds have antiproliferative activity against fungal pathogens and mammalian cancer cell lines. Analysis of E. gracilis extracts revealed that the algae produce not only the euglenatides, but also a corresponding family of analogs that have the same molecular weights as the euglenatides, but are lacking the characteristic triene chromophore. In comparison to the euglenatides, the activity of these analogs is greatly reduced in a mammalian cytotoxicity assay, indicating that the triene is critical to the biological activity of the euglenatides.
裸藻肽是由单细胞藻类纤细裸藻产生的一类混合聚酮化合物-非核糖体肽。这些化合物对真菌病原体和哺乳动物癌细胞系具有抗增殖活性。对纤细裸藻提取物的分析表明，该藻类不仅产生裸藻肽，还产生了相应的一类类似物，它们与裸藻肽具有相同的分子量，但缺乏特征性的三烯发色团。与裸藻肽相比，这些类似物在哺乳动物细胞毒性试验中的活性大大降低，这表明三烯对裸藻肽的生物活性至关重要。
