Kaye Alan D, Boullion Jolie A, Abdelsalam Mariem, Green Melanie A, Nguyen Angela, MacDonald Ellie M, Dastgah Mehdi, Ballaera Corrado, Ahmadzadeh Shahab, Mychaskiw Ii George, Shekoohi Sahar, Robinson Christopher L
Departments of Anesthesiology and Pharmacology, Toxicology, and Neurosciences, Louisiana State University Health Sciences Center at Shreveport, 1501 Kings Highway, Shreveport, LA, 71103, USA.
School of Medicine, Louisiana State University Health Sciences Center at Shreveport, 1501 Kings Highway, Shreveport, LA, 71103, USA.
Curr Pain Headache Rep. 2025 Jan 6;29(1):13. doi: 10.1007/s11916-024-01320-9.
Knee osteoarthritis (OA) is a gradual deterioration of articular cartilage characterized by pain and physical dysfunction. Although analgesic pharmacological agents are the first-line treatment for knee OA, they are not effective for all patients. In this study, we evaluate the efficacy of an intra-articular injection treatment using platelet-rich plasma (PRP) in reducing pain and improving functional ability.
Following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, this systematic review and meta-analysis (SR/MA) provides an updated overview for the role of PRP in knee OA treatment. Ten articles, published between 2016 and 2023, met the inclusion criteria and compared PRP treatment to a placebo control at six-month follow-up. A total of 9,409 potential studies were identified from a review of four different databases: PubMed (n = 4595), Cochrane (n = 4252), VHL (n = 112), and OpenSigle (n = 450). After the titles and abstracts and inclusion and exclusion criteria were considered, a total of 10 studies were analyzed. Although a significant improvement among PRP-treated groups in some studies was found, there was variability such as where the aforementioned scores appeared to worsen and some only demonstrated trends. Overall, PRP may be a promising treatment for symptomatic knee OA. However, further research is necessary to determine the efficacy of PRP in treating knee OA, with specific considerations for times at follow-up, frequency and dosage of injections, and comorbidities, which were unaccounted for in this SR/MA.
膝关节骨关节炎（OA）是一种以疼痛和身体功能障碍为特征的关节软骨逐渐退化疾病。尽管止痛药物是膝关节OA的一线治疗方法，但并非对所有患者都有效。在本研究中，我们评估了富血小板血浆（PRP）关节内注射治疗在减轻疼痛和改善功能能力方面的疗效。
遵循系统评价和Meta分析的首选报告项目（PRISMA）指南，本系统评价和Meta分析（SR/MA）提供了PRP在膝关节OA治疗中作用的最新概述。2016年至2023年发表的10篇文章符合纳入标准，并在六个月随访时将PRP治疗与安慰剂对照进行了比较。通过对四个不同数据库的检索共识别出9409项潜在研究：PubMed（n = 4595）、Cochrane（n = 4252）、VHL（n = 112）和OpenSigle（n = 450）。在考虑标题、摘要以及纳入和排除标准后，共分析了10项研究。尽管在一些研究中发现PRP治疗组有显著改善，但存在变异性，例如上述评分似乎恶化，有些仅显示出趋势。总体而言，PRP可能是有症状膝关节OA的一种有前景的治疗方法。然而，有必要进一步研究以确定PRP治疗膝关节OA的疗效，特别要考虑随访时间、注射频率和剂量以及合并症，而本SR/MA中未涉及这些因素。
