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一维光子晶体生物传感设计的白癜风检测能力

Vitiligo detection capabilities of 1D photonic crystal biosensing design.

作者信息

Alshomrany Ali S, Aly Arafa H, Mohamed B A, Alamri S, Mohamed D, Awasthi S K, Matar Zinab S, Amin A F, Hanafy H

机构信息

Department of Physics, College of Sciences, Umm Al-Qura University, Al Taif HWY, Mecca, 24381, Saudi Arabia.

Physics Department, Faculty of Sciences, TH-PPM Group, Beni-Suef University, Beni Suef, 62514, Egypt.

出版信息

Sci Rep. 2025 Jan 6;15(1):883. doi: 10.1038/s41598-024-83421-4.

DOI:10.1038/s41598-024-83421-4
PMID:39762338
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11704009/
Abstract

This theoretical work focuses on the application of Tamm resonance-based biosensing using a one-dimensional photonic crystal for detecting skin vitiligo, a condition caused by the loss of pigment in the body. This biosensor utilizes the interaction of light with the photonic structure to identify the specific biomarkers associated with vitiligo. The proposed structure is composed of prism/Ag/skin-sample/(GaP/PS)/glass. The MATLAB simulations are used to obtain numerical results pertaining to the work by using the transfer matrix method (TMM). The analysis of transmission spectra of the proposed structure shows its minute sensing ability of detecting skin vitiligo. The proposed sensor possesses a higher sensitivity of 1200 nm/RIU which is higher than the sensitivities of the sensor reported earlier. Moreover, the suggested biosensor possesses an extremely high-quality factor value of 40,650 with an exceptionally small full-width-half-maximum value of 0.04 nm.

摘要

这项理论研究聚焦于基于塔姆共振的生物传感技术在一维光子晶体检测皮肤白癜风中的应用，白癜风是一种由体内色素缺失引起的病症。这种生物传感器利用光与光子结构的相互作用来识别与白癜风相关的特定生物标志物。所提出的结构由棱镜/银/皮肤样本/（磷化镓/聚苯乙烯）/玻璃组成。利用MATLAB模拟，通过转移矩阵法（TMM）获得与该研究相关的数值结果。对所提出结构的透射光谱分析表明其对检测皮肤白癜风具有微小的传感能力。所提出的传感器具有1200 nm/RIU的更高灵敏度，高于先前报道的传感器灵敏度。此外，所建议的生物传感器具有40,650的极高品质因数，其半高宽极小，仅为0.04 nm。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8169/11704009/830beec95a7f/41598_2024_83421_Fig11_HTML.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8169/11704009/4deabda54044/41598_2024_83421_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8169/11704009/aea19d21ee4f/41598_2024_83421_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8169/11704009/45fc54f175fd/41598_2024_83421_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8169/11704009/3a6781d80951/41598_2024_83421_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8169/11704009/ae04bed86943/41598_2024_83421_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8169/11704009/94eb1833dea0/41598_2024_83421_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8169/11704009/906c886b0863/41598_2024_83421_Fig9_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8169/11704009/d1084ab699c5/41598_2024_83421_Fig10_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8169/11704009/830beec95a7f/41598_2024_83421_Fig11_HTML.jpg

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