Department of Surgery, Teikyo University School of Medicine, Tokyo, Japan;
Department of Surgery, Teikyo University School of Medicine, Tokyo, Japan.
In Vivo. 2022 Jan-Feb;36(1):450-457. doi: 10.21873/invivo.12724.
It has been shown that nutritional status and inflammation correlate with survival in patients with various cancer types. In this study, we evaluated several kinds of nutritional and inflammation parameters in preoperative blood samples and constructed new risk model predicting survival in patients with colorectal cancer.
We retrospectively examined 286 patients with stage I-III colorectal cancer who had undergone curative resection at Teikyo University Hospital. The association between overall survival (OS) and nutritional status and inflammation factors were examined using Kaplan-Meier curves and log-rank tests.
Serum albumin, cholesterol and C-reactive protein concentration, neutrophil count and platelet count were shown to be correlated with OS. We constructed a new risk model (nutrition inflammation status, NIS) using these factors, and compared it with other nutrition and inflammation models.
NIS was useful as a new model for predicting OS in patients undergoing curative resection for colorectal cancer, compared with known models.
已有研究表明，营养状况和炎症与多种癌症患者的生存相关。本研究旨在评估术前血液样本中多种营养和炎症参数，并构建新的风险模型预测结直肠癌患者的生存情况。
我们回顾性分析了在帝京大学医院接受根治性切除术的 286 例 I-III 期结直肠癌患者。使用 Kaplan-Meier 曲线和对数秩检验评估总生存期（OS）与营养状况和炎症因素之间的关系。
血清白蛋白、胆固醇和 C 反应蛋白浓度、中性粒细胞计数和血小板计数与 OS 相关。我们使用这些因素构建了一个新的风险模型（营养炎症状态，NIS），并将其与其他营养和炎症模型进行了比较。
与已知模型相比，NIS 可作为预测结直肠癌根治性切除术后 OS 的新模型。
