Ardila Padilla Carlos A, Vignoni Mariana, Serrano Mariana P, Dántola M Laura
Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas (INIFTA), Departamento de Química, Facultad de Ciencias Exactas, Universidad Nacional de La Plata, CCT La Plata-CONICET. B1904DPI, 1900 La Plata, Buenos Aires, Argentina.
Chem Res Toxicol. 2025 Jan 20;38(1):182-192. doi: 10.1021/acs.chemrestox.4c00401. Epub 2025 Jan 6.
UVA radiation and visible light can lead to indirect damage to DNA, proteins, and lipids through photosensitized reactions, where a molecule undergoes a photochemical alteration by the initial absorption of radiation by another molecular entity called photosensitizer (Sens). The chemical changes undergone by biomolecules in photosensitized reactions can trigger important adverse processes such as photoallergy, phototoxicity, and skin cancer, among others. Despite the knowledge about photosensitized reactions and the fact that many endogenous compounds present in the skin can act as Sens, UVA, and visible light are widely used in several devices for domestic and general use without a thorough evaluation of their possible harmful effects; one prominent example is UV-nail polish dryers. The information in the literature about the possible damage that can be caused by using this type of radiation source is controversial. In this work, we demonstrate that the radiation dose emitted by the nail polish dryer device during a typical gel nail manicure session effectively degrades molecules present in the skin under physiological and pathological conditions. Additionally, it may induce damage to biomolecules such as proteins and lipids due to the photosensitization process, leading to the loss of their biological functions.
紫外线A辐射和可见光可通过光敏反应导致对DNA、蛋白质和脂质的间接损伤，在光敏反应中，一个分子通过被另一个称为光敏剂（Sens）的分子实体最初吸收辐射而发生光化学改变。生物分子在光敏反应中发生的化学变化可引发重要的不良过程，如光过敏、光毒性和皮肤癌等。尽管人们了解光敏反应，且皮肤中存在的许多内源性化合物可充当光敏剂，但紫外线A和可见光仍被广泛用于多种家用和通用设备中，却未对其可能的有害影响进行全面评估；一个突出的例子是紫外线美甲烘干机。文献中关于使用此类辐射源可能造成的损害的信息存在争议。在这项工作中，我们证明，在典型的凝胶美甲过程中，美甲烘干机设备发出的辐射剂量在生理和病理条件下能有效降解皮肤中存在的分子。此外，由于光敏化过程，它可能会对蛋白质和脂质等生物分子造成损害，导致其生物学功能丧失。
