Garg Muskan, Liu Xingyi, Lin Jie, Vassilaki Maria, Petersen Ronald C, St Sauver Jennifer, Kapoor Ekta, Sohn Sunghwan
medRxiv. 2024 Dec 29:2024.12.27.24319704. doi: 10.1101/2024.12.27.24319704.
A scoping review was conducted to investigate knowledge gaps in the informatics research literature regarding sex differences in cognitive decline, identifying existing studies and areas where further studies are needed.
We searched Ovid and other databases for studies on sex differences and cognitive decline, focusing on publications in peer-reviewed informatics journals and conference proceedings from 2000 to 2023. The selected manuscripts were analyzed and summarized through discussion among three reviewers.
A total of 13 articles were selected and examined for metadata and attributes analysis. Most studies are conducted in United States (n=5) and European Union (n=4), about a half are published after 2020 (n=6), and most studies are published in Springer and Elsevier. Our attributes-based analysis highlights the different aspects of reported studies such as task, method, dataset and its size, and sex-specific inferences.
Sex-specific disparities in cognitive decline remain a critical issue in healthcare, yet most informatics research has primarily concentrated on identifying basic sex differences, such as tracking the progression of cognitive decline in men and women. While these studies are valuable, they fall short of addressing the more complex underlying causes of these sex-specific disparities in progression of cognitive decline.
There is a significant gap using informatics in understanding how biological, social, and behavioral factors contribute to sex-specific disparities. This limited focus restricts the development of effective intervention strategies for mitigating sex-specific differences in cognitive health outcomes, underscoring the need for more comprehensive research that goes beyond mere identification to find the root cause of these disparities in healthcare.
进行了一项范围综述，以调查信息学研究文献中关于认知衰退性别差异的知识空白，确定现有研究以及需要进一步研究的领域。
我们在Ovid和其他数据库中搜索关于性别差异和认知衰退的研究，重点关注2000年至2023年同行评审的信息学期刊和会议论文集中的出版物。通过三位评审员的讨论对选定的手稿进行分析和总结。
共筛选出13篇文章进行元数据和属性分析。大多数研究在美国（n = 5）和欧盟（n = 4）进行，约一半在2020年后发表（n = 6），且大多数研究发表在施普林格和爱思唯尔出版社。我们基于属性的分析突出了已报道研究的不同方面，如任务、方法、数据集及其规模以及性别特异性推断。
认知衰退中的性别特异性差异在医疗保健中仍然是一个关键问题，但大多数信息学研究主要集中在识别基本的性别差异，如追踪男性和女性认知衰退的进展。虽然这些研究很有价值，但它们未能解决这些认知衰退进展中性别特异性差异的更复杂潜在原因。
在利用信息学理解生物、社会和行为因素如何导致性别特异性差异方面存在重大差距。这种有限的关注限制了减轻认知健康结果中性别特异性差异的有效干预策略的发展，强调需要进行更全面的研究，不仅仅是识别，还要找到医疗保健中这些差异的根本原因。
