García Herrera Iris Paola, Canales Robredo Carlos, Aboytes Zavala Magdalena, Merayo Chalico Javier, Pineda Arzate Orfanel Sebastian, Colín Ortíz José Luis, Aparicio Vera Luis Alberto
Pediatric Rheumatology Department, Hospital Para El Niño Poblano, Puebla, Mexico.
Pediatric Department, Hospital Para El Niño Poblano, Puebla, Mexico.
Front Pediatr. 2024 Dec 20;12:1410400. doi: 10.3389/fped.2024.1410400. eCollection 2024.
A female patient in middle childhood was diagnosed with coarctation of the aorta at one month of age and underwent a successful cortectomy. At 11 years old, she developed re-coarctation, which was managed through interventional cardiology. Shortly after the procedure, she experienced a sudden and severe clinical decline, presenting with hypoperfusion of the lower extremities, gastrointestinal bleeding, acute kidney injury, and pancreatitis. Multiple thrombotic events were identified, prompting an extensive evaluation for thrombophilia The patient tested positive for antiphospholipid antibodies and was diagnosed with catastrophic antiphospholipid antibody syndrome (CAPS). An aggressive treatment was initiated, yielding a favorable response following discharge; she made a full recovery and continues to be monitored regularly in cardiology and rheumatology clinics.
一名童年中期的女性患者在1个月大时被诊断出患有主动脉缩窄,并成功接受了缩窄切除术。11岁时,她出现了再狭窄,通过介入心脏病学进行了治疗。手术后不久,她突然出现严重的临床病情恶化,表现为下肢灌注不足、胃肠道出血、急性肾损伤和胰腺炎。发现了多次血栓形成事件,促使对易栓症进行广泛评估。患者抗磷脂抗体检测呈阳性,被诊断为灾难性抗磷脂抗体综合征(CAPS)。开始了积极的治疗,出院后取得了良好的反应;她完全康复,继续在心脏病学和风湿病诊所定期接受监测。