有氧运动对2型糖尿病患者通过连续血糖监测测得的24小时平均血糖水平的影响：一项荟萃分析。
The effects of aerobic exercise on 24-hour mean blood glucose levels measured by continuous glucose monitoring in type 2 diabetes: a meta-analysis.
作者信息
Wang Chou, Tang Shaokai
机构信息
School of Sport, Health and Exercise, Loughborough University, Loughborough, United Kingdom.
College of Sports Science, Jishou University, Jishou, China.
出版信息
Front Physiol. 2024 Dec 23;15:1496271. doi: 10.3389/fphys.2024.1496271. eCollection 2024.
PURPOSE
To examine the effects of structured aerobic exercise on 24-hour mean blood glucose outcomes assessed by continuous glucose monitors in adults with type 2 diabetes.
METHODS
The study established specific inclusion and exclusion criteria and conducted a comprehensive search across five databases, including PubMed, Web of Science, Embase, Cochrane Library, and EBSCOhost from the start year of each database's coverage to 22 July 2024. The quality of the included studies was evaluated using the Cochrane Handbook 5.1 guidelines. Data analysis was performed using Review Manager 5.4 to determine effect sizes, conduct sensitivity analyses, assess potential biases, and perform subgroup analyses.
RESULTS
A total of 1,034 articles were retrieved, and after 4 rounds of screening, 13 articles were finally selected for meta-analysis. The study included 626 participants (30% female; mean ± SD: age, 59.4 ± 6.4 years; BMI, 29.61 ± 2.24 kg/m), including 330 in the experimental group and 296 in the control group. The results of the meta-analysis showed that aerobic exercise can improve the 24-hour mean blood glucose in patients with T2DM (d = -0.65, 95% CI: -0.75 to -0.55, < 0.05). Subgroup analysis showed that moderate-intensity and high-intensity aerobic exercise can improve the 24-hour mean blood glucose in patients with T2DM (d = -0.71, 95% CI: -0.81 to -0.60, < 0.05), (d = -0.60, 95% CI: -0.98 to -0.22, < 0.05). Also, 20-40 min and 40-60 min of aerobic exercise per session can improve the 24-hour average blood glucose in patients with T2DM (d = -0.75, 95% CI: -0.91 to -0.59, < 0.05), (d = -0.59, 95% CI: -0.71 to -0.46, < 0.05). Aerobic exercise can improve the 24-hour mean blood glucose in patients with T2DM who have a body mass index (BMI) between 29 and 30 kg/m, as well as those with a BMI greater than 30 kg/m (d = -0.65, 95% CI: -0.94 to -0.36, < 0.05), (d = -0.76, 95% CI: -0.87 to -0.64, < 0.05).
CONCLUSION
Aerobic exercise can improve the 24-hour mean blood glucose in patients with T2DM. Additionally, 20-60 min of aerobic exercise with moderate intensity, and high intensity can improve the 24-hour mean blood glucose in patients with T2DM who have a BMI greater than 29 kg/m.
SYSTEMATIC REVIEW REGISTRATION
https://www.crd.york.ac.uk/prospero/, identifer PROSPERO CRD42024590812.
目的
探讨结构化有氧运动对2型糖尿病成人患者通过连续血糖监测仪评估的24小时平均血糖结果的影响。
方法
本研究制定了具体的纳入和排除标准，并对五个数据库进行了全面检索，包括PubMed、Web of Science、Embase、Cochrane图书馆和EBSCOhost，检索时间从每个数据库的收录起始年份至2024年7月22日。使用Cochrane手册5.1指南评估纳入研究的质量。使用Review Manager 5.4进行数据分析，以确定效应大小、进行敏感性分析、评估潜在偏倚并进行亚组分析。
结果
共检索到1034篇文章，经过四轮筛选，最终选择13篇文章进行荟萃分析。该研究纳入了626名参与者（30%为女性；平均±标准差：年龄，59.4±6.4岁；体重指数，29.61±2.24kg/m²），其中实验组330人，对照组296人。荟萃分析结果显示，有氧运动可改善2型糖尿病患者的24小时平均血糖（d=-0.65，95%置信区间：-0.75至-0.55，P<0.05）。亚组分析表明，中等强度和高强度有氧运动均可改善2型糖尿病患者的24小时平均血糖（d=-0.71，95%置信区间：-0.81至-0.60，P<0.05），（d=-0.60，95%置信区间：-0.98至-0.22，P<0.05）。此外，每次进行20 - 40分钟和40 - 60分钟的有氧运动均可改善2型糖尿病患者的24小时平均血糖（d=-0.75，95%置信区间：-0.91至-0.59，P<0.05），（d=-0.59，95%置信区间：-0.71至-0.46，P<0.05）。有氧运动可改善体重指数（BMI）在29至30kg/m²之间以及BMI大于30kg/m²的2型糖尿病患者的24小时平均血糖（d=-0.65，95%置信区间：-0.94至-0.36，P<0.05），（d=-0.76，95%置信区间：-0.87至-0.64，P<0.05）。
结论
有氧运动可改善2型糖尿病患者的24小时平均血糖。此外，20 - 60分钟的中等强度和高强度有氧运动可改善BMI大于29kg/m²的2型糖尿病患者的24小时平均血糖。
系统评价注册
https://www.crd.york.ac.uk/prospero/，标识符PROSPERO CRD42024590812。
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