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A deep learning framework for virtual continuous glucose monitoring and glucose prediction based on life-log data.

作者信息

Lim Min Hyuk, Chae Hyocheol, Yoon Jeongwon, Shin Insik

机构信息

Graduate School of Health Science and Technology, Ulsan National Institute of Science and Technology (UNIST), 50 UNIST-gil, Eonyang-eup, Ulju-gun, Ulsan, 44919, Republic of Korea.

Artificial Intelligence Graduate School, Ulsan National Institute of Science and Technology (UNIST), 50 UNIST-gil, Eonyang-eup, Ulju-gun, Ulsan, 44919, Republic of Korea.

出版信息

Sci Rep. 2025 May 10;15(1):16290. doi: 10.1038/s41598-025-01367-7.


DOI:10.1038/s41598-025-01367-7
PMID:40348812
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12065870/
Abstract

While continuous glucose monitoring (CGM) has revolutionized metabolic health management, widespread adoption remains limited by cost constraints and usage burden, often resulting in interrupted monitoring periods. We propose a deep learning framework for glucose level inference that operates independently of prior glucose measurements, utilizing comprehensive life-log data. The model employs a bidirectional Long Short-Term Memory (LSTM) network with an encoder-decoder architecture, incorporating dual attention mechanisms for temporal and feature importance. The system was trained on data from 171 healthy adults, encompassing detailed records of dietary intake, physical activity metrics, and glucose measurements. The encoder's hidden state as latent representations were analyzed for distributions of patterns of glucose and life-log sequences. The model showed a 19.49 ± 5.42 (mg/dL) in Root Mean Squared Error, 0.43 ± 0.2 in correlation coefficient, and 12.34 ± 3.11 (%) in Mean Absolute Percentage Eror for current glucose level predictions without any information of glucose at the inference step. The distribution of latent representations from the encoder showed the potential differentiation for glucose patterns. The model's ability to maintain predictive accuracy during periods of CGM unavailability has the potential to support intermittent monitoring scenarios for users.

摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fe40/12065870/a7485ee5a989/41598_2025_1367_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fe40/12065870/ac5a700fb36f/41598_2025_1367_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fe40/12065870/f7ba71ffafb6/41598_2025_1367_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fe40/12065870/86f0cc8dc090/41598_2025_1367_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fe40/12065870/0df8a8de061e/41598_2025_1367_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fe40/12065870/8008bba11649/41598_2025_1367_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fe40/12065870/a7485ee5a989/41598_2025_1367_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fe40/12065870/ac5a700fb36f/41598_2025_1367_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fe40/12065870/f7ba71ffafb6/41598_2025_1367_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fe40/12065870/86f0cc8dc090/41598_2025_1367_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fe40/12065870/0df8a8de061e/41598_2025_1367_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fe40/12065870/8008bba11649/41598_2025_1367_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fe40/12065870/a7485ee5a989/41598_2025_1367_Fig6_HTML.jpg

相似文献

[1]
A deep learning framework for virtual continuous glucose monitoring and glucose prediction based on life-log data.

Sci Rep. 2025-5-10

[2]
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[3]
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[4]
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[5]
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[6]
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[7]
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[8]
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[9]
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[10]
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本文引用的文献

[1]
Review of Over the Counter and Prescription Continuous Glucose Monitoring.

J Pharm Pract. 2025-3-19

[2]
SRM-Net: Joint Sampling and Reconstruction and Mapping Network for Accelerated 3T Brain Multi-Parametric MR Imaging.

IEEE Trans Biomed Eng. 2025-6

[3]
Expert Clinical Interpretation of Continuous Glucose Monitor Reports From Individuals Without Diabetes.

J Diabetes Sci Technol. 2025-2-12

[4]
Is there a role for continuous glucose monitoring beyond diabetes? Emerging applications in new populations.

Expert Rev Med Devices. 2025-3

[5]
The effects of aerobic exercise on 24-hour mean blood glucose levels measured by continuous glucose monitoring in type 2 diabetes: a meta-analysis.

Front Physiol. 2024-12-23

[6]
Prediction of metabolic subphenotypes of type 2 diabetes via continuous glucose monitoring and machine learning.

Nat Biomed Eng. 2024-12-23

[7]
Establishing methods to monitor H5N1 influenza virus in dairy cattle milk.

medRxiv. 2024-12-5

[8]
Personalized Blood Glucose Forecasting From Limited CGM Data Using Incrementally Retrained LSTM.

IEEE Trans Biomed Eng. 2025-4

[9]
Integrating Bayesian Approaches and Expert Knowledge for Forecasting Continuous Glucose Monitoring Values in Type 2 Diabetes Mellitus.

IEEE J Biomed Health Inform. 2025-2

[10]
Insertable Glucose Sensor Using a Compact and Cost-Effective Phosphorescence Lifetime Imager and Machine Learning.

ACS Nano. 2024-8-27

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