鳄梨树及其衍生物在糖尿病管理中的作用：一种控制血糖的自然方法。
The role of avocado plant and its derivatives in the management of diabetes mellitus: a natural approach to glycemic control.
作者信息
Agunloye Mary Olaoluwa, Owu Daniel U, Onaadepo Olufunke, Bisong Sunday A, Ogunyemi Oludare Michael, Ugwu Felix Nnaemeka
机构信息
Department of Physiology, Kampala International University, Western Campus, Ishaka, Uganda.
Department of Physiology, College of Medical Sciences, University of Calabar, Calabar, Nigeria.
出版信息
J Diabetes Metab Disord. 2025 Jan 4;24(1):34. doi: 10.1007/s40200-024-01551-y. eCollection 2025 Jun.
PURPOSE
Diabetes mellitus is a global health challenge that leads to severe complications, negatively impacting overall health, life expectancy, and quality of life. Herbal medicines, valued for their accessibility and therapeutic benefits with minimal side effects, have been promoted as potential treatments. Managing conditions like diabetes, characterized by free radical production and cytokine-driven inflammation, is vital due to the active components in plants that exert direct pharmacological effects. This review explores the therapeutic potential of Mill plant (avocado) in diabetes management and its potential targets.
METHODS
A comprehensive review of relevant published literature was conducted using keywords such as ("avocado plant" or "") and ("diabetes"). Data were collected from scholarly databases, including Google Scholar, PubMed, and Science Direct.
RESULTS
(avocado) is rich in bioactive compounds, including flavonoids, oleic acid, phenolics, vitamins, alkaloids, tannins, α-carotene, saponins, β-carotene, and lutein. These components help alleviate the harmful effects of diabetes by reducing β-cell apoptosis and inflammation. They also combat oxidative stress, inhibit specific enzymes, and scavenge free radicals. Furthermore, avocado bioactives influence key pathways critical to diabetes management, such as the PI3K/Akt signaling pathway and the regulation of glucose metabolism.
CONCLUSION
The biological properties of the parts of plant underscore its potential as a complementary medicinal approach to diabetes management. Additionally, its role in improving cardiovascular health, often compromised in diabetics, highlights its broader therapeutic value. Future studies could explore avocado's impact on specific pathways associated with diabetes mellitus, such as mTOR, Wnt/β-Catenin, AMPK, JAK-STAT, ROS-ERK-NF-κB, and IGF pathways, as current information on this pathways remains limited.
目的
糖尿病是一项全球性的健康挑战，会导致严重并发症，对整体健康、预期寿命和生活质量产生负面影响。草药因其易获取性和治疗益处且副作用最小而受到重视，已被推广为潜在的治疗方法。由于植物中的活性成分具有直接的药理作用，对于以自由基产生和细胞因子驱动的炎症为特征的糖尿病等病症进行管理至关重要。本综述探讨了牛油果植物在糖尿病管理中的治疗潜力及其潜在靶点。
方法
使用诸如（“牛油果植物”或“”）和（“糖尿病”）等关键词对相关已发表文献进行全面综述。数据从包括谷歌学术、PubMed和科学Direct在内的学术数据库中收集。
结果
牛油果富含生物活性化合物，包括黄酮类、油酸、酚类、维生素、生物碱、单宁、α - 胡萝卜素、皂苷、β - 胡萝卜素和叶黄素。这些成分通过减少β细胞凋亡和炎症来帮助减轻糖尿病的有害影响。它们还对抗氧化应激、抑制特定酶并清除自由基。此外，牛油果生物活性物质影响对糖尿病管理至关重要的关键途径，如PI3K/Akt信号通路和葡萄糖代谢的调节。
结论
牛油果植物各部分的生物学特性凸显了其作为糖尿病管理辅助药物方法的潜力。此外，它在改善糖尿病患者常受损的心血管健康方面的作用突出了其更广泛的治疗价值。由于目前关于mTOR、Wnt/β - 连环蛋白、AMPK、JAK - STAT、ROS - ERK - NF - κB和IGF途径等与糖尿病相关的特定途径的信息仍然有限，未来的研究可以探索牛油果对这些途径的影响。
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