Cui Sunny, Aronno Mubtaseem, Wong Angel K Q, Snodgrass Leah
Department of Biological Sciences, Dartmouth College, Hanover, NH, USA.
Schulich School of Medicine and Dentistry, Western University, London, ON, Canada.
Commun Integr Biol. 2025 Jan 2;18(1):2446332. doi: 10.1080/19420889.2024.2446332. eCollection 2025.
Emerging research has highlighted the significant role of microbiota-gut-brain communication in child psychiatric disorders, including autism spectrum disorder (ASD) and anxiety disorders. Despite this, mainstream psychiatric interventions for children continue to focus predominantly on neurological and psychological therapies, neglecting the critical influence of gut microbiota on brain development and behavior. This commentary underscores the need for greater integration of microbiota-targeted therapies, such as dietary interventions, prebiotics, and probiotics, into early psychiatric intervention strategies. By addressing the gut-brain axis as a key component of neurodevelopmental and psychiatric outcomes, clinicians can adopt a more holistic and biologically informed approach to treatment. We propose that future research and clinical practice should prioritize interdisciplinary collaboration to explore how microbiota-based treatments can be incorporated into existing child psychiatry frameworks, offering new avenues for improving long-term mental health outcomes.
新兴研究突出了微生物群-肠-脑通讯在儿童精神疾病中的重要作用,包括自闭症谱系障碍(ASD)和焦虑症。尽管如此,针对儿童的主流精神科干预措施仍主要集中在神经和心理治疗上,而忽视了肠道微生物群对大脑发育和行为的关键影响。这篇评论强调了将以微生物群为靶点的疗法,如饮食干预、益生元和益生菌,更多地纳入早期精神科干预策略的必要性。通过将肠-脑轴作为神经发育和精神科结果的关键组成部分来处理,临床医生可以采用更全面且基于生物学知识的治疗方法。我们建议,未来的研究和临床实践应优先进行跨学科合作,以探索如何将基于微生物群的治疗方法纳入现有的儿童精神病学框架,为改善长期心理健康结果提供新途径。