Abdurashtov Arkady S, Proshin Pavel I, Sukhorukov Gleb B
Vladimir Zelman Center for Neurobiology and Brain Rehabilitation, Skoltech, Moscow, Russia.
Life Improvement by Future Technologies (LIFT) Center, Moscow, Russia.
Expert Opin Drug Deliv. 2025 Feb;22(2):219-238. doi: 10.1080/17425247.2024.2448026. Epub 2025 Jan 9.
The pursuit of linear dosage in pharmacy is essential for achieving consistent therapeutic release and enhancing patient compliance. This review provides a comprehensive summary of zero-order drug delivery systems, with a particular focus on reservoir-based systems emanated from different microfabrication technologies.
The consideration of recent advances in drug delivery systems is given to encompass the key areas including the importance of achieving a constant drug release rate for therapeutic applications. Detailed examination of reservoir-based systems, their design, mechanisms of action and materials used are highlighted. By addressing these areas, the discussion aims to provide a thorough understanding of most recent zero-order drug delivery systems, their performance advantages and methods of their manufacturing. To ensure the complete coverage of the explored research area, modern AI-assistant tools were used to find not only the most relevant, but also connected and similar articles.
Future developments in reservoir-based drug delivery systems are expected to significantly enhance therapeutic effectiveness and patient outcomes through the integration of innovative materials and technologies. The fabrication of intelligent drug delivery systems that utilize sensors and feedback mechanisms can enable real-time monitoring of drug release and patient reactions.
在药学中追求线性剂量对于实现一致的治疗释放和提高患者依从性至关重要。本综述全面总结了零级给药系统，特别关注源自不同微加工技术的基于储库的系统。
对药物递送系统的最新进展进行了考量，包括实现治疗应用中恒定药物释放速率的重要性等关键领域。重点详细考察了基于储库的系统、其设计、作用机制和所用材料。通过探讨这些领域，旨在全面了解最新的零级给药系统、其性能优势及其制造方法。为确保全面覆盖所探索的研究领域，使用了现代人工智能辅助工具来查找不仅最相关，而且有联系和相似的文章。
基于储库的药物递送系统的未来发展有望通过整合创新材料和技术显著提高治疗效果和患者预后。利用传感器和反馈机制的智能药物递送系统的制造能够实现对药物释放和患者反应的实时监测。
