Speed Shannon N, Sherman Garrick T, Wang Tammy, Pince Claire L, Sanfilippo Jenna E, Montemitro Chiara, Giorgi Salvatore, Curtis Brenda L, Farinelli Lisa A, Farokhnia Mehdi, Leggio Lorenzo
Clinical Psychoneuroendocrinology and Neuropsychopharmacology Section, Translational Addiction Medicine Branch, National Institute on Drug Abuse Intramural Research Program and National Institute on Alcohol Abuse and Alcoholism Division of Intramural Clinical and Biological Research, National Institutes of Health, Bethesda, Baltimore, MD, USA.
Office of the Clinical Director, National Institute on Drug Abuse Intramural Research Program, Baltimore, MD, USA.
Drug Alcohol Depend. 2025 Feb 1;267:112529. doi: 10.1016/j.drugalcdep.2024.112529. Epub 2024 Dec 26.
Studies suggest alcohol and/or other substance misuse may develop after bariatric surgery (BS), but findings are not consistent or conclusive.
This cross-sectional online survey investigated alcohol and other substance use, via a modified version of the Alcohol Use Disorders Identification Test, before and after bariatric surgery, compared to a non-bariatric surgery sample. Data were anonymously collected via Qualtrics from adults who reported alcohol or substance use (BS, n = 328; non-BS, n = 292).
Problematic alcohol, opioid, amphetamine, and cannabis use were reduced post-surgery compared to pre-surgery. After surgery, participants expressed "guilt" associated with alcohol and other substance use (average 0.24 and 0.31 points higher, respectively) compared to pre-surgery. Compared to controls, the bariatric surgery group reported on average 1.99 points less problematic nicotine use pre-surgery (p = .012) and 2.42 points less post-surgery (p = .004). In contrast, compared to people without any history of bariatric surgery, the bariatric surgery group reported greater problematic use of alcohol, cannabis, hallucinogens, and/or inhalants pre-surgery (all p < .001); same results were found post-surgery for all drugs, (all p < .001) except for hallucinogens which was not significantly different between the two groups.
Unlike previous reports, these survey-based results do not show an increase in problematic alcohol and substance use following bariatric surgery. Recall biases and the survey-based methodology are however important limitations of the present study. The observed increase in "guilt" associated with substance use may align with growing evidence suggesting increased subjective response to alcohol and other substances following bariatric surgery.
研究表明，减肥手术后可能会出现酒精和/或其他物质滥用的情况，但研究结果并不一致或具有决定性。
这项横断面在线调查通过酒精使用障碍识别测试的修改版本，对减肥手术前后的酒精和其他物质使用情况进行了调查，并与非减肥手术样本进行了比较。数据通过Qualtrics从报告有酒精或物质使用情况的成年人中匿名收集（减肥手术组，n = 328；非减肥手术组，n = 292）。
与术前相比，术后有问题的酒精、阿片类药物、苯丙胺和大麻使用情况有所减少。手术后，与术前相比，参与者表达了与酒精和其他物质使用相关的“内疚感”（分别平均高出0.24和0.31分）。与对照组相比，减肥手术组术前报告的有问题尼古丁使用情况平均少1.99分（p = 0.012），术后少2.42分（p = 0.004）。相比之下，与没有任何减肥手术史的人相比，减肥手术组术前报告的酒精、大麻、致幻剂和/或吸入剂的问题使用情况更多（所有p < 0.001）；除致幻剂外，两组术后所有药物的情况相同（所有p < 0.001），致幻剂在两组之间没有显著差异。
与之前的报告不同，这些基于调查的结果并未显示减肥手术后有问题的酒精和物质使用情况增加。然而，回忆偏差和基于调查的方法是本研究的重要局限性。观察到的与物质使用相关的“内疚感”增加可能与越来越多的证据一致，这些证据表明减肥手术后对酒精和其他物质的主观反应增加。
