Anderson R A, Bryden N A, Polansky M M
Am J Clin Nutr. 1985 Mar;41(3):571-7. doi: 10.1093/ajcn/41.3.571.
Seventy-six adult subjects, 48 males and 28 females, were given placebo or 200 micrograms Cr in the form of chromic chloride in a double-blind crossover study, with 3-month experimental periods, to determine basal serum Cr levels and the effects of Cr supplementation on serum Cr and related variables. Basal serum Cr determined by graphite furnace atomic absorption for all subjects was 0.13 +/- 0.02 ng/ml (mean +/- SEM), and increased significantly to 0.38 +/- 0.02 ng/ml following 3 months of Cr supplementation. There were no significant differences in the serum Cr values for males and females. Serum Cr 90 min following a glucose load (1 g per kg body wt) was not significantly different from fasting during either the placebo or Cr supplementation periods. These data demonstrate that serum Cr increased significantly following Cr supplementation and is a reflection of Cr intake, but serum Cr concentration, even that following a glucose load, does not appear to be a meaningful indicator of Cr status.
在一项双盲交叉研究中，76名成年受试者（48名男性和28名女性）被给予安慰剂或200微克氯化铬形式的铬，实验期为3个月，以确定基础血清铬水平以及补充铬对血清铬和相关变量的影响。通过石墨炉原子吸收法测定，所有受试者的基础血清铬为0.13±0.02纳克/毫升（平均值±标准误），补充铬3个月后显著升高至0.38±0.02纳克/毫升。男性和女性的血清铬值无显著差异。在安慰剂期或补充铬期，葡萄糖负荷（每千克体重1克）后90分钟的血清铬与空腹时无显著差异。这些数据表明，补充铬后血清铬显著升高，反映了铬的摄入量，但血清铬浓度，即使是葡萄糖负荷后的浓度，似乎也不是铬状态的有意义指标。
