Ricci Agnese, Stefanuto Luca, Gasperi Tecla, Bruni Fabio, Tofani Daniela
Department of Science, Section of Nanoscience and Nanotechnologies, "Roma Tre" University, Via della Vasca Navale 79, 00146 Rome, Italy.
Department of Science, Section of Nanoscience and Nanotechnologies, "Roma Tre" University, Via della Vasca Navale 84, 00146 Rome, Italy.
Antioxidants (Basel). 2024 Dec 12;13(12):1516. doi: 10.3390/antiox13121516.
The skin, being the largest organ of the human body, serves as the primary barrier against external insults, including UV radiation, pollutants, and microbial pathogens. However, prolonged exposure to these environmental stressors can lead to the generation of reactive oxygen species (ROS), causing oxidative stress, inflammation, and ultimately, skin aging and diseases. Antioxidants play a crucial role in neutralizing ROS and preserving skin health by preventing oxidative damage. In recent years, nanotechnology has emerged as a powerful tool for enhancing the delivery of antioxidants onto the skin. In particular, liposomal formulations have offered unique advantages such as improved stability, controlled release, and enhanced penetration through the skin barrier. This has led to a surge in research focused on developing liposomal-based antioxidant delivery systems tailored for skin health applications. Through a comprehensive analysis of the literature from the 2019-2024 period, this review provides an overview of emerging trends in the use of liposomal delivery systems developed for antioxidants aimed at improving skin health. It explores the latest advancements in liposomal formulation strategies, vesicle characterization, and their applications in delivering antioxidants to combat oxidative stress-induced skin damage and other associated skin pathologies. A comparison of various delivery systems is conducted for the most common antioxidants. Finally, a brief analysis of lipid nanovesicles used in the cosmeceutical industry is provided.
皮肤作为人体最大的器官，是抵御外部侵害的主要屏障，这些侵害包括紫外线辐射、污染物和微生物病原体。然而，长期暴露于这些环境应激源会导致活性氧（ROS）的产生，引发氧化应激、炎症，最终导致皮肤衰老和疾病。抗氧化剂通过防止氧化损伤来中和ROS并维持皮肤健康，发挥着至关重要的作用。近年来，纳米技术已成为增强抗氧化剂向皮肤递送的有力工具。特别是，脂质体制剂具有独特的优势，如稳定性提高、控释以及增强透过皮肤屏障的能力。这导致了专注于开发针对皮肤健康应用的基于脂质体的抗氧化剂递送系统的研究激增。通过对2019 - 2024年期间文献的全面分析，本综述概述了为改善皮肤健康而开发的用于抗氧化剂的脂质体递送系统的新兴趋势。它探讨了脂质体制剂策略、囊泡表征的最新进展，以及它们在递送抗氧化剂以对抗氧化应激诱导的皮肤损伤和其他相关皮肤病理方面的应用。对最常见的抗氧化剂的各种递送系统进行了比较。最后，对化妆品行业中使用的脂质纳米囊泡进行了简要分析。
