基于DNA甲基化的液体活检在肿瘤诊疗中的研究进展
Research Progress of Liquid Biopsy Based on DNA Methylation in Tumor Diagnosis and Treatment.
作者信息
Bao Yunxia, Wang Xianzhao, Zeng Bingjie, Shi Yichun, Huang Yiman, Huang Yiwen, Shang Shuang, Shan Liang, Ma Lifang
机构信息
Department of Clinical Laboratory Medicine, Shanghai Chest Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200030, China.
College of Health Science and Technology, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
出版信息
Biomolecules. 2024 Dec 19;14(12):1634. doi: 10.3390/biom14121634.
Liquid biopsy has been gradually applied to the clinical diagnosis and treatment of tumors because of its non-invasive and real-time reflection of the tumor status, as well as the convenience of sample collection, which allows the detection of primary or metastatic malignant tumors and reflects the heterogeneity of the tumors. DNA methylation, which is a type of epigenetic modification, is essential in the progression of tumors. This review introduces the common DNA methylation analysis methods and discusses their advantages and disadvantages, focusing on the new progress of DNA methylation-based liquid biopsy in tumor diagnosis and treatment.
液体活检因其能够无创、实时反映肿瘤状态以及样本采集方便，已逐渐应用于肿瘤的临床诊断和治疗，这使得其能够检测原发性或转移性恶性肿瘤，并反映肿瘤的异质性。DNA甲基化作为一种表观遗传修饰，在肿瘤进展中至关重要。本文综述介绍了常见的DNA甲基化分析方法，并讨论了它们的优缺点，重点阐述了基于DNA甲基化的液体活检在肿瘤诊断和治疗方面的新进展。
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