Benfica Poliana, Scianni Aline, Magalhães Jordana, Brito Sherindan, Martins Júlia, Faria Christina
Department of Physical Therapy, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte 31270-901, Minas Gerais, Brazil.
Department of Physical Therapy, Faculdade Ciências Médicas de Minas Gerais (FCMMG), Belo Horizonte 30130-110, Minas Gerais, Brazil.
Brain Sci. 2024 Nov 28;14(12):1198. doi: 10.3390/brainsci14121198.
BACKGROUND/OBJECTIVES: Bradykinesia is considered one of the most disabling motor symptoms in individuals with Parkinson's disease (PD). Speed-based interventions are promising for reducing bradykinesia in this population. This systematic review aims to describe speed-based interventions that have been employed for reducing bradykinesia in individuals with PD and verify their effects.
This systematic review protocol was carried out in accordance with the Preferred Reporting Items for Systematic Review and Meta-Analysis Protocols (PRISMA-P). Electronic searches were performed in MEDLINE, EMBASE, PEDro, LILACS and SciELO databases and gray literature sources. Experimental studies that investigated the effects of speed-based interventions on bradykinesia in individuals with PD will be considered. Two independent reviewers will screen the studies, extract data and assess risk of bias using Revised Cochrane risk-of-bias tool for randomized trials (RoB 2) and ROBINS-I ("Risk Of Bias In Non-randomised Studies-of Interventions"). Grading of Recommendations Assessment, Development and Evaluation (GRADE) will be used to assed the quality of evidence.
This systematic review will offer information regarding which types of speed-based interventions have been investigated for reducing bradykinesia in individuals with PD. This information may be important for clinical decision making and will help identify gaps in the literature that may be useful for the definition of future research objectives and the planning of new trials. Ethical permission is not required for this study.
this systematic review was registered with the International Prospective Register of Systematic Reviews (PROSPERO; registration number: CRD42024543673).
背景/目的：运动迟缓被认为是帕金森病（PD）患者中最致残的运动症状之一。基于速度的干预措施有望减轻该人群的运动迟缓。本系统评价旨在描述已用于减轻PD患者运动迟缓的基于速度的干预措施，并验证其效果。
本系统评价方案按照系统评价与Meta分析方案的首选报告项目（PRISMA-P）进行。在MEDLINE、EMBASE、PEDro、LILACS和SciELO数据库以及灰色文献来源中进行电子检索。将考虑调查基于速度的干预措施对PD患者运动迟缓影响的实验研究。两名独立的评审员将筛选研究、提取数据，并使用随机试验的修订Cochrane偏倚风险工具（RoB 2）和ROBINS-I（“干预性非随机研究中的偏倚风险”）评估偏倚风险。推荐分级评估、制定和评价（GRADE）将用于评估证据质量。
本系统评价将提供有关已研究哪些类型的基于速度的干预措施来减轻PD患者运动迟缓的信息。这些信息可能对临床决策很重要，并将有助于识别文献中的空白，这些空白可能有助于确定未来的研究目标和规划新的试验。本研究无需伦理许可。
本系统评价已在国际前瞻性系统评价注册库（PROSPERO；注册号：CRD42024543673）注册。
