Tan Chao-Ren, Qiao Meng, Chang Jin, Chen Shu-Min, Wang Yingying
Institute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences, Beijing, People's Republic of China.
Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing, People's Republic of China.
BMJ Open. 2025 Apr 3;15(4):e095435. doi: 10.1136/bmjopen-2024-095435.
Substance use disorders (SUDs) are common and highly disabling, causing serious long-term harm to people's health. Despite the existence of evidence-based interventions for treating SUDs, many individuals remain symptomatic regardless of treatment, and relapse is common. Acupuncture has been examined for the treatment of SUDs, but available evidence is mixed. This comprehensive systematic review and meta-analysis aims to provide updated evidence which will include both English and Chinese studies to investigate the effectiveness and safety of different types of acupuncture for the treatment of alcohol, tobacco and illicit drug use disorders.
This protocol is guided by the Preferred Reporting Items for Systematic Reviews and Meta Analysis Protocols. A thorough search for relevant studies in multiple electronic databases (PubMed, Embase, PsycINFO, Cochrane Library, China National Knowledge Infrastructure, VIP, Wan-fang and China Biomedical Database) and clinical trial registries will be conducted. Population-Intervention-Comparator-Outcomes-Study design criteria will be adopted for study inclusion. Only randomised controlled trials analysing the efficacy and safety of acupuncture for SUDs will be included. Two reviewers will independently conduct the study selection, data extraction and quality assessment, and disagreements will be solved by a third senior reviewer or by contacting study authors. Frequency and quantity of substance use, abstinence rate, withdrawal symptoms, treatment drop-out and relapse rates are primary outcomes. Functional status, health-related quality of life and adverse events are secondary outcomes. The risk of bias and quality of evidence will be assessed by the revised Cochrane risk-of-bias tool for randomised trials and guidelines of the Grading of Recommendations Assessment, Development and Evaluation working group, respectively. When sufficient data is available, subgroup analyses will be performed to further compare the differences in the primary and secondary outcomes based on the type of substance use, acupuncture, co-intervention status, comparison group, measurement tools, length of follow-up, risk of bias of included studies and countries of studies conducted.
No private information is used in the entire process of the systematic review. Therefore, ethical approval is not required. Findings of the proposed systematic review will be published in a peer-reviewed journal and/or disseminated through conference presentations.
The protocol has been archived in the Prospero repository (PROSPERO 2024 CRD42024566389).
物质使用障碍（SUDs）很常见且具有高度致残性，会对人们的健康造成严重的长期损害。尽管存在基于证据的治疗SUDs的干预措施，但许多人无论接受何种治疗仍有症状，且复发很常见。针刺已被用于研究治疗SUDs，但现有证据不一。本全面的系统评价和荟萃分析旨在提供最新证据，其中将包括英文和中文研究，以调查不同类型针刺治疗酒精、烟草和非法药物使用障碍的有效性和安全性。
本方案遵循系统评价和荟萃分析方案的首选报告项目。将在多个电子数据库（PubMed、Embase、PsycINFO、Cochrane图书馆、中国知网、维普、万方和中国生物医学数据库）以及临床试验注册库中全面检索相关研究。研究纳入将采用人群-干预-对照-结局-研究设计标准。仅纳入分析针刺治疗SUDs有效性和安全性的随机对照试验。两名评价者将独立进行研究选择、数据提取和质量评估，分歧将由第三位资深评价者解决或与研究作者联系解决。物质使用的频率和量、戒断率、戒断症状、治疗退出率和复发率为主要结局。功能状态、与健康相关的生活质量和不良事件为次要结局。将分别采用修订后的Cochrane随机试验偏倚风险工具和推荐分级评估、制定与评价工作组的指南评估偏倚风险和证据质量。当有足够数据时，将进行亚组分析，以根据物质使用类型、针刺、联合干预状态、对照组、测量工具、随访时间、纳入研究的偏倚风险和研究开展国家进一步比较主要和次要结局的差异。
在系统评价的整个过程中不使用私人信息。因此，无需伦理批准。拟议的系统评价结果将发表在同行评审期刊上和/或通过会议报告进行传播。
该方案已存档于国际前瞻性系统评价注册库（PROSPERO 2024 CRD42024566389）。
