肌萎缩侧索硬化症的营养治疗：系统评价和荟萃分析方案。
Nutritional therapy in amyotrophic lateral sclerosis: protocol for a systematic review and meta-analysis.
机构信息
Postgraduate Program in Health Sciences, Federal University of Rio Grande do Norte, Natal, Brazil.
Laboratory of Technological Innovation in Health (LAIS), Federal University of Rio Grande do Norte, Natal, Brazil.
出版信息
BMJ Open. 2022 Aug 25;12(8):e064086. doi: 10.1136/bmjopen-2022-064086.
INTRODUCTION
Amyotrophic lateral sclerosis (ALS) is a complex neurodegenerative disease characterised by the degeneration of motor neurons. Nutritional interventions in ALS are essential and must be based on scientific evidence to provide quality of healthcare, improve the quality of life and increase survival time. Therefore, this protocol of systematic reviews and meta-analyses aims to present a synthesis of evidence-based recommendations to support adequate nutrition therapy for patients with ALS.
METHODS AND ANALYSIS
The search will be performed using the following databases: PubMed, Excerpta Medica Database (Embase), Scopus, SciELO, Web of Science, LILACS, Cochrane Central Register of Controlled Trials (CENTRAL), ScienceDirect, ProQuest and Google Scholar. We will include clinical practice guidelines, treatment protocols, systematic reviews and clinical trials according to the three research questions to be answered related to nutrition therapy and interventions in patients with ALS. This protocol will be developed in accordance with the Preferred Reporting Items for Systematic Review and Meta-analysis Protocols. To evaluate the methodological quality of the studies, Appraisal of Guidelines, Research and Evaluation II, Cochrane Risk of Bias 2.0 and Risk of Bias In Non-randomized Studies of Interventions (ROBINS-I) tools will be used. In addition, the Grading of Recommendations Assessment, Development and Evaluation will be used to assess the quality of evidence and the strength of the recommendations. The findings will be summarised and presented descriptively according to the Cochrane Collaboration Handbook and the standard statistical meta-analysis techniques.
ETHICS AND DISSEMINATION
Ethical approval and human consent are not required because this is a protocol for systematic review and only secondary data will be used. Findings will be published in a peer-reviewed journal and presented at conferences. In case of any changes in this protocol, amendments will be updated in International Prospective Register of Systematic Reviews (PROSPERO) and the modifications will be explained in the final report of this review.
PROSPERO REGISTRATION NUMBER
CRD42021233088.
简介
肌萎缩侧索硬化症（ALS）是一种复杂的神经退行性疾病，其特征是运动神经元的退化。ALS 中的营养干预至关重要，必须基于科学证据，以提供医疗保健质量，提高生活质量并延长生存时间。因此，本系统评价和荟萃分析的方案旨在提出基于证据的建议综合，以支持 ALS 患者的适当营养治疗。
方法和分析
搜索将使用以下数据库进行：PubMed、Excerpta Medica Database（Embase）、Scopus、SciELO、Web of Science、LILACS、Cochrane 中央对照试验注册（CENTRAL）、ScienceDirect、ProQuest 和 Google Scholar。我们将包括临床实践指南、治疗方案、系统评价和临床试验，根据要回答的与 ALS 患者营养治疗和干预相关的三个研究问题进行。本方案将按照系统评价和荟萃分析方案的首选报告项目制定。为了评估研究的方法学质量，将使用评估指南、研究和评价 II、Cochrane 偏倚风险 2.0 和非随机干预研究的偏倚风险（ROBINS-I）工具。此外，将使用推荐评估、制定和评估分级来评估证据质量和推荐强度。将根据 Cochrane 协作手册和标准统计荟萃分析技术对研究结果进行总结和描述性呈现。
伦理和传播
由于这是系统评价的方案，并且仅使用二次数据，因此不需要伦理批准和人类同意。研究结果将发表在同行评议的期刊上，并在会议上展示。如果本方案有任何更改，将在国际前瞻性系统评价注册库（PROSPERO）中更新修正案，并在本综述的最终报告中解释修改内容。
PROSPERO 注册号：CRD42021233088。
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