Domán Marianna, Pintér Krisztina, Pollák Boglárka Dóra, Pintér Ágnes, Wehmann Enikő, Tenk Miklós, Magyar Tibor
HUN-REN Veterinary Medical Research Institute, 1143 Budapest, Hungary.
Department of Microbiology and Infectious Diseases, University of Veterinary Medicine, 1143 Budapest, Hungary.
Antibiotics (Basel). 2024 Dec 22;13(12):1235. doi: 10.3390/antibiotics13121235.
: The One Health approach is crucial for managing and controlling the spread of antimicrobial resistance. is a recently identified bacterial species that seems to be a component of the oral microbiota of dogs; however, its pathogenic nature is questionable. : In this study, the antibacterial susceptibility of isolates was determined using the disk diffusion and broth microdilution methods. Genome-wide comparative analyses were performed to identify the genetic factors driving virulence and antimicrobial drug resistance (e.g., virulence factors, antimicrobial resistance genes (ARGs) and prophage-related sequences). : Most of the isolates lacked virulence-associated genes. is likely resistant to clindamycin, lincomycin and neomycin, but susceptible to penicillin, erythromycin and enrofloxacin. Antimicrobial resistance genes were not found in the genomes, but prophage-related sequences were identified, suggesting its potential in the transfer of genes associated with drug resistance between bacteria in the oral microbiome. : is presumably a commensal organism with low virulence potential, as evidenced by the absence of virulence-associated genes. As can colonize a wide range of hosts, including humans, further investigation with a greater number of isolates is needed to better understand the role of in disease development and the spread of drug resistance.
“同一健康”方法对于管理和控制抗菌药物耐药性的传播至关重要。[某菌名]是最近发现的一种细菌物种，似乎是犬类口腔微生物群的一个组成部分；然而，其致病性质存在疑问。在本研究中，使用纸片扩散法和肉汤微量稀释法测定了[某菌名]分离株的抗菌药敏性。进行了全基因组比较分析，以确定驱动毒力和抗菌药物耐药性的遗传因素（例如，毒力因子、抗菌耐药基因（ARGs）和前噬菌体相关序列）。大多数[某菌名]分离株缺乏与毒力相关的基因。[某菌名]可能对克林霉素、林可霉素和新霉素耐药，但对青霉素、红霉素和恩诺沙星敏感。在[某菌名]基因组中未发现抗菌耐药基因，但鉴定出了前噬菌体相关序列，这表明其在口腔微生物群中细菌之间转移与耐药性相关基因方面具有潜力。[某菌名]据推测是一种毒力潜力较低的共生生物，缺乏与毒力相关的基因证明了这一点。由于[某菌名]可以在包括人类在内的广泛宿主中定殖，因此需要对更多分离株进行进一步研究，以更好地了解[某菌名]在疾病发展和耐药性传播中的作用。
