Wang Yicheng, Chen Haotian, Zhang Zhijin, He Yanyan, Liu Ji, Zhao Baoshuang, Wang Qinwan, Xu Jiangmei, Mao Shiyu, Zhang Wentao, Yao Xudong, Li Wei
Department of Urology, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai 200072, China.
School of Medicine, Tongji University, Shanghai 200092, China.
Biomedicines. 2024 Nov 27;12(12):2708. doi: 10.3390/biomedicines12122708.
When a patient has two or more primary tumors, excluding the possibility of diffuse, recurrent, or metastatic, they can be defined as having multiple primary malignant neoplasms (MPMNs). Moreover, cases of three primary urinary tract tumors are very rare. Here, we reported a patient of MPMNs with four primary tumors, including three urinary tract cancers (renal cancer, prostate cancer, and bladder cancer) and lung cancer. The four tumors appeared over 13 years, and pathological results confirmed that they were all primary tumors after different surgeries. In addition, we established patient-derived organoids (PDOs) by collecting tumor specimens. Hematoxylin-eosin (H&E) staining of PDOs showed that the organoids were histopathological consistent with parental tumor. Immunohistochemistry showed that PDOs can also reflect the expression of pathological markers in patients. At the same time, PDOs may also serve as "avatars" of patients to predict sensitivity to different drugs. In summary, we reported a case of MPMNs with four primary tumors and established PDOs from its tumor specimens. A personalized treatment strategy was established based on the histopathological characteristics of the organoids.
当患者有两个或更多原发性肿瘤，排除弥漫性、复发性或转移性的可能性时，可定义为患有多原发性恶性肿瘤（MPMNs）。此外，三原发性泌尿系统肿瘤的病例非常罕见。在此，我们报告了一例患有MPMNs且有四个原发性肿瘤的患者，包括三种泌尿系统癌症（肾癌、前列腺癌和膀胱癌）以及肺癌。这四个肿瘤在13年期间出现，不同手术的病理结果证实它们均为原发性肿瘤。此外，我们通过收集肿瘤标本建立了患者来源的类器官（PDOs）。PDOs的苏木精-伊红（H&E）染色显示，类器官在组织病理学上与亲本肿瘤一致。免疫组织化学显示，PDOs也能反映患者病理标志物的表达。同时，PDOs还可作为患者的“替身”来预测对不同药物的敏感性。总之，我们报告了一例有四个原发性肿瘤的MPMNs病例，并从其肿瘤标本中建立了PDOs。基于类器官的组织病理学特征制定了个性化的治疗策略。
